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Stereo(C7)‐dependent Topoisomerase II Inhibition and Tumor Growth Suppression by a New Quinolone, BO‐2367

A new antimicrobial quinolone (—)BO‐2367, (‐)‐7‐[(1R*,2R*,6R*)‐2‐amino‐8‐azabicyclo[4.3.0.]‐non‐3‐en‐8‐yl]‐l‐cyclopropyl‐6,8‐difluoro‐l,4‐dihydro‐4‐oxo‐3‐quinorinecarboxyric acid, strongly inhibited both mammalian and bacterial topoisomerase II. The IC(50) values of (—)BO‐2367 against the DNA relaxa...

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Detalles Bibliográficos
Autores principales:	Yoshinari, Tomoko, Mano, Eiichi, Arakawa, Hiroharu, Kurama, Masae, Iguchi, Tomoko, Nakagawa, Susumu, Tanaka, Nobuo, Okura, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1993
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919197/ https://www.ncbi.nlm.nih.gov/pubmed/8396568 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02047.x

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