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HTLV‐1‐associated Myelopathy/Tropical Spastic Paraparesis‐like Rats by Intravenous Injection of HTLV‐1‐producing Rabbit or Human T‐Cell Line into Adult WKA Rats

We intravenously injected Ra‐1 cells or MT‐2 cells into female adult WKA rats. Spastic paraparesis mainly in the hind‐limbs was observed in 1 out of 2 Ra‐1 cell‐injected WKA rats and in 3 out of 8 MT‐2 cell‐injected WKA rats 20 27 months after injection. The main neuropathological finding was symmet...

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Autores principales: Kushida, Shigeki, Matsumura, Masayuki, Tanaka, Hiroko, Ami, Yoshihiro, Hori, Mitsuo, Kobayashi, Mikirou, Uchida, Kazuhiko, Yagami, Ken‐ichi, Kameyama, Tsuneo, Yoshizawa, Toshihiro, Mizusawa, Hidehiro, Iwasaki, Yuzo, Miwa, Masanao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919272/
https://www.ncbi.nlm.nih.gov/pubmed/8407544
http://dx.doi.org/10.1111/j.1349-7006.1993.tb02052.x
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author Kushida, Shigeki
Matsumura, Masayuki
Tanaka, Hiroko
Ami, Yoshihiro
Hori, Mitsuo
Kobayashi, Mikirou
Uchida, Kazuhiko
Yagami, Ken‐ichi
Kameyama, Tsuneo
Yoshizawa, Toshihiro
Mizusawa, Hidehiro
Iwasaki, Yuzo
Miwa, Masanao
author_facet Kushida, Shigeki
Matsumura, Masayuki
Tanaka, Hiroko
Ami, Yoshihiro
Hori, Mitsuo
Kobayashi, Mikirou
Uchida, Kazuhiko
Yagami, Ken‐ichi
Kameyama, Tsuneo
Yoshizawa, Toshihiro
Mizusawa, Hidehiro
Iwasaki, Yuzo
Miwa, Masanao
author_sort Kushida, Shigeki
collection PubMed
description We intravenously injected Ra‐1 cells or MT‐2 cells into female adult WKA rats. Spastic paraparesis mainly in the hind‐limbs was observed in 1 out of 2 Ra‐1 cell‐injected WKA rats and in 3 out of 8 MT‐2 cell‐injected WKA rats 20 27 months after injection. The main neuropathological finding was symmetrical white matter degeneration with mononuclear cell infiltration of the spinal cord, similar to that of HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, and degeneration of nerve roots and peripheral nerves. Antibodies against HTLV‐1 antigens were detected in plasma and cerebrospinal fluid from these HAM/TSP‐like rats. HTLV‐1 provirus was detected from the peripheral blood mononuclear cells of one of these rats 20 months after injection. Interestingly, spastic paraparesis was not observed in F344 rats.
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spelling pubmed-59192722018-05-11 HTLV‐1‐associated Myelopathy/Tropical Spastic Paraparesis‐like Rats by Intravenous Injection of HTLV‐1‐producing Rabbit or Human T‐Cell Line into Adult WKA Rats Kushida, Shigeki Matsumura, Masayuki Tanaka, Hiroko Ami, Yoshihiro Hori, Mitsuo Kobayashi, Mikirou Uchida, Kazuhiko Yagami, Ken‐ichi Kameyama, Tsuneo Yoshizawa, Toshihiro Mizusawa, Hidehiro Iwasaki, Yuzo Miwa, Masanao Jpn J Cancer Res Article We intravenously injected Ra‐1 cells or MT‐2 cells into female adult WKA rats. Spastic paraparesis mainly in the hind‐limbs was observed in 1 out of 2 Ra‐1 cell‐injected WKA rats and in 3 out of 8 MT‐2 cell‐injected WKA rats 20 27 months after injection. The main neuropathological finding was symmetrical white matter degeneration with mononuclear cell infiltration of the spinal cord, similar to that of HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, and degeneration of nerve roots and peripheral nerves. Antibodies against HTLV‐1 antigens were detected in plasma and cerebrospinal fluid from these HAM/TSP‐like rats. HTLV‐1 provirus was detected from the peripheral blood mononuclear cells of one of these rats 20 months after injection. Interestingly, spastic paraparesis was not observed in F344 rats. Blackwell Publishing Ltd 1993-08 /pmc/articles/PMC5919272/ /pubmed/8407544 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02052.x Text en
spellingShingle Article
Kushida, Shigeki
Matsumura, Masayuki
Tanaka, Hiroko
Ami, Yoshihiro
Hori, Mitsuo
Kobayashi, Mikirou
Uchida, Kazuhiko
Yagami, Ken‐ichi
Kameyama, Tsuneo
Yoshizawa, Toshihiro
Mizusawa, Hidehiro
Iwasaki, Yuzo
Miwa, Masanao
HTLV‐1‐associated Myelopathy/Tropical Spastic Paraparesis‐like Rats by Intravenous Injection of HTLV‐1‐producing Rabbit or Human T‐Cell Line into Adult WKA Rats
title HTLV‐1‐associated Myelopathy/Tropical Spastic Paraparesis‐like Rats by Intravenous Injection of HTLV‐1‐producing Rabbit or Human T‐Cell Line into Adult WKA Rats
title_full HTLV‐1‐associated Myelopathy/Tropical Spastic Paraparesis‐like Rats by Intravenous Injection of HTLV‐1‐producing Rabbit or Human T‐Cell Line into Adult WKA Rats
title_fullStr HTLV‐1‐associated Myelopathy/Tropical Spastic Paraparesis‐like Rats by Intravenous Injection of HTLV‐1‐producing Rabbit or Human T‐Cell Line into Adult WKA Rats
title_full_unstemmed HTLV‐1‐associated Myelopathy/Tropical Spastic Paraparesis‐like Rats by Intravenous Injection of HTLV‐1‐producing Rabbit or Human T‐Cell Line into Adult WKA Rats
title_short HTLV‐1‐associated Myelopathy/Tropical Spastic Paraparesis‐like Rats by Intravenous Injection of HTLV‐1‐producing Rabbit or Human T‐Cell Line into Adult WKA Rats
title_sort htlv‐1‐associated myelopathy/tropical spastic paraparesis‐like rats by intravenous injection of htlv‐1‐producing rabbit or human t‐cell line into adult wka rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919272/
https://www.ncbi.nlm.nih.gov/pubmed/8407544
http://dx.doi.org/10.1111/j.1349-7006.1993.tb02052.x
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