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Benign Breast Disease as a Breast Cancer Risk in Japanese Women
A hospital‐based retrospective cohort study of benign breast disease (BBD) as a risk factor of future breast cancer (BC) development was conducted. Four hundred and twenty‐eight patients with biopsied BBD were followed‐up for a median period of 8 years, together with age‐matched women with normal br...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1993
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919282/ https://www.ncbi.nlm.nih.gov/pubmed/8407559 http://dx.doi.org/10.1111/j.1349-7006.1993.tb00181.x |
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author | Nomura, Yasuo Tashiro, Hideya Katsuda, Yasaburo |
author_facet | Nomura, Yasuo Tashiro, Hideya Katsuda, Yasaburo |
author_sort | Nomura, Yasuo |
collection | PubMed |
description | A hospital‐based retrospective cohort study of benign breast disease (BBD) as a risk factor of future breast cancer (BC) development was conducted. Four hundred and twenty‐eight patients with biopsied BBD were followed‐up for a median period of 8 years, together with age‐matched women with normal breasts (normal control) and BC patients (cancer control), at the ratio of 1:2:2. Twenty‐one breast cancers developed, 7 in the cases, 4 in the normal controls, and 10 in the BC controls, showing the relative risk (RR) with 95% confidence intervals (CD to be 3.5 (1.03–11.9) in the cases with respect to the normal controls. The RR of the cases is not lower than that of contralateral breast cancer incidence. There were no significant differences in the risks of cancers in other organs among the groups. Pathological examination revealed that only atypical hyperplasia increased the RR of BC, as compared with the normal control breast group, or with non‐proliferative disease. These results suggest that in a low‐risk country, Japan, BBD is a definite risk factor for BC development as in high‐risk countries. |
format | Online Article Text |
id | pubmed-5919282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1993 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59192822018-05-11 Benign Breast Disease as a Breast Cancer Risk in Japanese Women Nomura, Yasuo Tashiro, Hideya Katsuda, Yasaburo Jpn J Cancer Res Article A hospital‐based retrospective cohort study of benign breast disease (BBD) as a risk factor of future breast cancer (BC) development was conducted. Four hundred and twenty‐eight patients with biopsied BBD were followed‐up for a median period of 8 years, together with age‐matched women with normal breasts (normal control) and BC patients (cancer control), at the ratio of 1:2:2. Twenty‐one breast cancers developed, 7 in the cases, 4 in the normal controls, and 10 in the BC controls, showing the relative risk (RR) with 95% confidence intervals (CD to be 3.5 (1.03–11.9) in the cases with respect to the normal controls. The RR of the cases is not lower than that of contralateral breast cancer incidence. There were no significant differences in the risks of cancers in other organs among the groups. Pathological examination revealed that only atypical hyperplasia increased the RR of BC, as compared with the normal control breast group, or with non‐proliferative disease. These results suggest that in a low‐risk country, Japan, BBD is a definite risk factor for BC development as in high‐risk countries. Blackwell Publishing Ltd 1993-09 /pmc/articles/PMC5919282/ /pubmed/8407559 http://dx.doi.org/10.1111/j.1349-7006.1993.tb00181.x Text en |
spellingShingle | Article Nomura, Yasuo Tashiro, Hideya Katsuda, Yasaburo Benign Breast Disease as a Breast Cancer Risk in Japanese Women |
title | Benign Breast Disease as a Breast Cancer Risk in Japanese Women |
title_full | Benign Breast Disease as a Breast Cancer Risk in Japanese Women |
title_fullStr | Benign Breast Disease as a Breast Cancer Risk in Japanese Women |
title_full_unstemmed | Benign Breast Disease as a Breast Cancer Risk in Japanese Women |
title_short | Benign Breast Disease as a Breast Cancer Risk in Japanese Women |
title_sort | benign breast disease as a breast cancer risk in japanese women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919282/ https://www.ncbi.nlm.nih.gov/pubmed/8407559 http://dx.doi.org/10.1111/j.1349-7006.1993.tb00181.x |
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