Chemical Modification of Natural Human Tumor Necrosis Factor‐α with Polyethylene Glycol Increases Its Anti‐tumor Potency

Natural human tumor necrosis factor‐α (TNF‐α) was chemically modified with an active ester of monomethoxy polyethylene glycol (PEG). The molecular weight of PEG‐modified TNF‐a depended on the reaction time as well as the initial molar ratio of PEG to TNF‐α. The specific activity of modified TNF‐α wa...

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Detalles Bibliográficos
Autores principales: Tsutsumi, Yasuo, Kihira, Tetsunari, Yamamoto, Susumu, Kubo, Kazuyoshi, Nakagawa, Shinsaku, Miyake, Masaharu, Horisawa, Yoshifumi, Kanamori, Toshinori, Ikegami, Hakuo, Mayumi, Tadanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919344/
https://www.ncbi.nlm.nih.gov/pubmed/8106293
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02879.x

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