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Effects of Cigarette Smoke on N‐Nitrosobis(2‐oxopropyl)amine‐induced Pancreatic and Respiratory Tumorigenesis in Hamsters

Influences of cigarette smoke on N‐nitrosobis(2‐oxopropyl)amine (BOP)‐induced pancreatic duct and respiratory tract tumorigenesis were investigated using a hamster two‐stage carcinogenesis model. Male 5‐week‐old hamsters were divided into 5 groups. Group 1 was s.c. injected with BOP at a dose of 10...

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Autores principales: Nishikawa, Akiyoshi, Furukawa, Fumio, Imazawa, Takayoshi, Yoshimura, Hiroyuki, Ikezaki, Shinichiro, Hayashi, Yuzo, Takahashi, Michihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919357/
https://www.ncbi.nlm.nih.gov/pubmed/7961101
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02897.x
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author Nishikawa, Akiyoshi
Furukawa, Fumio
Imazawa, Takayoshi
Yoshimura, Hiroyuki
Ikezaki, Shinichiro
Hayashi, Yuzo
Takahashi, Michihito
author_facet Nishikawa, Akiyoshi
Furukawa, Fumio
Imazawa, Takayoshi
Yoshimura, Hiroyuki
Ikezaki, Shinichiro
Hayashi, Yuzo
Takahashi, Michihito
author_sort Nishikawa, Akiyoshi
collection PubMed
description Influences of cigarette smoke on N‐nitrosobis(2‐oxopropyl)amine (BOP)‐induced pancreatic duct and respiratory tract tumorigenesis were investigated using a hamster two‐stage carcinogenesis model. Male 5‐week‐old hamsters were divided into 5 groups. Group 1 was s.c. injected with BOP at a dose of 10 mgAg once a week for 3 weeks as an initiation treatment together with cigarette smoke exposure over the same 4‐week period. Group 2 was exposed to cigarette smoke for 26 weeks after the BOP‐initiation. Groups 3 and 4 were respectively given the BOP‐initiation alone and the 26‐week cigarette smoke exposure without initiation. Group 5 served as a sham‐smoked negative control. The experiment was terminated 30 weeks after the first BOP injection. The incidence of pancreatic adenocarcinomas was significantly decreased in Group 1 as compared to the Group 3 value (P < 0.01) while the Group 2 value did not show any change. In contrast, the incidence of laryngeal and tracheal proliferative lesions (hyperplasias and papillomas) was significantly increased in Group 2 over Group 3 (P<0.01). The incidence of pulmonary hyperplasias was also increased in Group 2 over Group 3 (P<0.05), although that of pulmonary adenomas or adenocarcinomas was decreased in Group 2 as compared to the Group 3 value (P<0.01). Cigarette smoke exposure in the BOP‐initiation phase (Group 1) did not affect the development of respiratory proliferative lesions. No animals in Groups 4 and 5 developed any tumors in the pancreas or respiratory tract. Our results thus indicate that cigarette smoke exposure inhibits pancreatic carcinogenesis when given in the initiation phase, whereas it modulates (enhances or suppresses) the development of proliferative lesions in the respiratory tract if applied during the promotion stage to hamsters pretreated with BOP.
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spelling pubmed-59193572018-05-11 Effects of Cigarette Smoke on N‐Nitrosobis(2‐oxopropyl)amine‐induced Pancreatic and Respiratory Tumorigenesis in Hamsters Nishikawa, Akiyoshi Furukawa, Fumio Imazawa, Takayoshi Yoshimura, Hiroyuki Ikezaki, Shinichiro Hayashi, Yuzo Takahashi, Michihito Jpn J Cancer Res Article Influences of cigarette smoke on N‐nitrosobis(2‐oxopropyl)amine (BOP)‐induced pancreatic duct and respiratory tract tumorigenesis were investigated using a hamster two‐stage carcinogenesis model. Male 5‐week‐old hamsters were divided into 5 groups. Group 1 was s.c. injected with BOP at a dose of 10 mgAg once a week for 3 weeks as an initiation treatment together with cigarette smoke exposure over the same 4‐week period. Group 2 was exposed to cigarette smoke for 26 weeks after the BOP‐initiation. Groups 3 and 4 were respectively given the BOP‐initiation alone and the 26‐week cigarette smoke exposure without initiation. Group 5 served as a sham‐smoked negative control. The experiment was terminated 30 weeks after the first BOP injection. The incidence of pancreatic adenocarcinomas was significantly decreased in Group 1 as compared to the Group 3 value (P < 0.01) while the Group 2 value did not show any change. In contrast, the incidence of laryngeal and tracheal proliferative lesions (hyperplasias and papillomas) was significantly increased in Group 2 over Group 3 (P<0.01). The incidence of pulmonary hyperplasias was also increased in Group 2 over Group 3 (P<0.05), although that of pulmonary adenomas or adenocarcinomas was decreased in Group 2 as compared to the Group 3 value (P<0.01). Cigarette smoke exposure in the BOP‐initiation phase (Group 1) did not affect the development of respiratory proliferative lesions. No animals in Groups 4 and 5 developed any tumors in the pancreas or respiratory tract. Our results thus indicate that cigarette smoke exposure inhibits pancreatic carcinogenesis when given in the initiation phase, whereas it modulates (enhances or suppresses) the development of proliferative lesions in the respiratory tract if applied during the promotion stage to hamsters pretreated with BOP. Blackwell Publishing Ltd 1994-10 /pmc/articles/PMC5919357/ /pubmed/7961101 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02897.x Text en
spellingShingle Article
Nishikawa, Akiyoshi
Furukawa, Fumio
Imazawa, Takayoshi
Yoshimura, Hiroyuki
Ikezaki, Shinichiro
Hayashi, Yuzo
Takahashi, Michihito
Effects of Cigarette Smoke on N‐Nitrosobis(2‐oxopropyl)amine‐induced Pancreatic and Respiratory Tumorigenesis in Hamsters
title Effects of Cigarette Smoke on N‐Nitrosobis(2‐oxopropyl)amine‐induced Pancreatic and Respiratory Tumorigenesis in Hamsters
title_full Effects of Cigarette Smoke on N‐Nitrosobis(2‐oxopropyl)amine‐induced Pancreatic and Respiratory Tumorigenesis in Hamsters
title_fullStr Effects of Cigarette Smoke on N‐Nitrosobis(2‐oxopropyl)amine‐induced Pancreatic and Respiratory Tumorigenesis in Hamsters
title_full_unstemmed Effects of Cigarette Smoke on N‐Nitrosobis(2‐oxopropyl)amine‐induced Pancreatic and Respiratory Tumorigenesis in Hamsters
title_short Effects of Cigarette Smoke on N‐Nitrosobis(2‐oxopropyl)amine‐induced Pancreatic and Respiratory Tumorigenesis in Hamsters
title_sort effects of cigarette smoke on n‐nitrosobis(2‐oxopropyl)amine‐induced pancreatic and respiratory tumorigenesis in hamsters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919357/
https://www.ncbi.nlm.nih.gov/pubmed/7961101
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02897.x
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