Different Incidence of Loss of Heterozygosity on Chromosome 16q between Intraductal Papilloma and Intracystic Papillary Carcinoma of the Breast

Loss of heterozygosity (LOH) on chromosome 16q was examined in DNA isolated from 11 intraductal papillomas and 12 intracystic papillary adenocarcinomas of the breast. Such LOH was detected in 8 (67%) out of 12 intracystic papillary adenocarcinomas, and in 7 (64%) of 11 of these adenocarcinomas of lo...

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Detalles Bibliográficos
Autores principales: Tsuda, Hitoshi, Uei, Yoshio, Fukutomi, Takashi, Hirohashi, Setsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919359/
https://www.ncbi.nlm.nih.gov/pubmed/7961109
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02895.x
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author Tsuda, Hitoshi
Uei, Yoshio
Fukutomi, Takashi
Hirohashi, Setsuo
author_facet Tsuda, Hitoshi
Uei, Yoshio
Fukutomi, Takashi
Hirohashi, Setsuo
author_sort Tsuda, Hitoshi
collection PubMed
description Loss of heterozygosity (LOH) on chromosome 16q was examined in DNA isolated from 11 intraductal papillomas and 12 intracystic papillary adenocarcinomas of the breast. Such LOH was detected in 8 (67%) out of 12 intracystic papillary adenocarcinomas, and in 7 (64%) of 11 of these adenocarcinomas of low grade atypia (Grade 1), whereas it was not detected in 11 intraductal papillomas. Therefore, inactivation of tumor‐suppressor genes on chromosome 16q was suggested to be involved in acquisition of malignant phenotype rather than in tumorigenesis in mammary gland epithelial cell. Examination of LOH on I6q should he helpful for differential diagnosis of intracystic papillary tumors.
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spelling pubmed-59193592018-05-11 Different Incidence of Loss of Heterozygosity on Chromosome 16q between Intraductal Papilloma and Intracystic Papillary Carcinoma of the Breast Tsuda, Hitoshi Uei, Yoshio Fukutomi, Takashi Hirohashi, Setsuo Jpn J Cancer Res Rapid Communication Loss of heterozygosity (LOH) on chromosome 16q was examined in DNA isolated from 11 intraductal papillomas and 12 intracystic papillary adenocarcinomas of the breast. Such LOH was detected in 8 (67%) out of 12 intracystic papillary adenocarcinomas, and in 7 (64%) of 11 of these adenocarcinomas of low grade atypia (Grade 1), whereas it was not detected in 11 intraductal papillomas. Therefore, inactivation of tumor‐suppressor genes on chromosome 16q was suggested to be involved in acquisition of malignant phenotype rather than in tumorigenesis in mammary gland epithelial cell. Examination of LOH on I6q should he helpful for differential diagnosis of intracystic papillary tumors. Blackwell Publishing Ltd 1994-10 /pmc/articles/PMC5919359/ /pubmed/7961109 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02895.x Text en
spellingShingle Rapid Communication
Tsuda, Hitoshi
Uei, Yoshio
Fukutomi, Takashi
Hirohashi, Setsuo
Different Incidence of Loss of Heterozygosity on Chromosome 16q between Intraductal Papilloma and Intracystic Papillary Carcinoma of the Breast
title Different Incidence of Loss of Heterozygosity on Chromosome 16q between Intraductal Papilloma and Intracystic Papillary Carcinoma of the Breast
title_full Different Incidence of Loss of Heterozygosity on Chromosome 16q between Intraductal Papilloma and Intracystic Papillary Carcinoma of the Breast
title_fullStr Different Incidence of Loss of Heterozygosity on Chromosome 16q between Intraductal Papilloma and Intracystic Papillary Carcinoma of the Breast
title_full_unstemmed Different Incidence of Loss of Heterozygosity on Chromosome 16q between Intraductal Papilloma and Intracystic Papillary Carcinoma of the Breast
title_short Different Incidence of Loss of Heterozygosity on Chromosome 16q between Intraductal Papilloma and Intracystic Papillary Carcinoma of the Breast
title_sort different incidence of loss of heterozygosity on chromosome 16q between intraductal papilloma and intracystic papillary carcinoma of the breast
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919359/
https://www.ncbi.nlm.nih.gov/pubmed/7961109
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02895.x
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