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Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung
CD44 is a cell surface receptor that has been implicated in lymphocyte homing, hematopoiesis, cell migration and possibly also tumor metastasis. In the present study, expression of CD44 variant (CD44v) isoforms was analyzed in 23 lung cancer specimens together with corresponding normal lung tissues...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1994
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919360/ https://www.ncbi.nlm.nih.gov/pubmed/7530240 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02915.x |
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author | Washimi, Osuke Ueda, Ryuzo Ariyoshi, Yutaka Suyama, Mot okazu Seki, Tsuneo Takahashi, Toshitada Takahashi, Takashi |
author_facet | Washimi, Osuke Ueda, Ryuzo Ariyoshi, Yutaka Suyama, Mot okazu Seki, Tsuneo Takahashi, Toshitada Takahashi, Takashi |
author_sort | Washimi, Osuke |
collection | PubMed |
description | CD44 is a cell surface receptor that has been implicated in lymphocyte homing, hematopoiesis, cell migration and possibly also tumor metastasis. In the present study, expression of CD44 variant (CD44v) isoforms was analyzed in 23 lung cancer specimens together with corresponding normal lung tissues by Southern blot analysis coupled with reverse transcription‐polynterase chain reaction amplification. We found that CD44v isoforms were expressed in all lung cancer specimens, suggesting a possible role in the establishment of metastases by these highly malignant tumors, but normal tissues were also positive. This is in marked contrast to the previous reports of essentially negligible expression of CD44v isoforms in normal colon and breast, and suggests a physiological function in the lung. |
format | Online Article Text |
id | pubmed-5919360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1994 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59193602018-05-11 Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung Washimi, Osuke Ueda, Ryuzo Ariyoshi, Yutaka Suyama, Mot okazu Seki, Tsuneo Takahashi, Toshitada Takahashi, Takashi Jpn J Cancer Res Article CD44 is a cell surface receptor that has been implicated in lymphocyte homing, hematopoiesis, cell migration and possibly also tumor metastasis. In the present study, expression of CD44 variant (CD44v) isoforms was analyzed in 23 lung cancer specimens together with corresponding normal lung tissues by Southern blot analysis coupled with reverse transcription‐polynterase chain reaction amplification. We found that CD44v isoforms were expressed in all lung cancer specimens, suggesting a possible role in the establishment of metastases by these highly malignant tumors, but normal tissues were also positive. This is in marked contrast to the previous reports of essentially negligible expression of CD44v isoforms in normal colon and breast, and suggests a physiological function in the lung. Blackwell Publishing Ltd 1994-11 /pmc/articles/PMC5919360/ /pubmed/7530240 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02915.x Text en |
spellingShingle | Article Washimi, Osuke Ueda, Ryuzo Ariyoshi, Yutaka Suyama, Mot okazu Seki, Tsuneo Takahashi, Toshitada Takahashi, Takashi Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung |
title | Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung |
title_full | Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung |
title_fullStr | Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung |
title_full_unstemmed | Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung |
title_short | Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung |
title_sort | expression of cd44 variant isoforms in normal and neoplastic cells of the lung |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919360/ https://www.ncbi.nlm.nih.gov/pubmed/7530240 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02915.x |
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