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Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung

CD44 is a cell surface receptor that has been implicated in lymphocyte homing, hematopoiesis, cell migration and possibly also tumor metastasis. In the present study, expression of CD44 variant (CD44v) isoforms was analyzed in 23 lung cancer specimens together with corresponding normal lung tissues...

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Detalles Bibliográficos
Autores principales: Washimi, Osuke, Ueda, Ryuzo, Ariyoshi, Yutaka, Suyama, Mot okazu, Seki, Tsuneo, Takahashi, Toshitada, Takahashi, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919360/
https://www.ncbi.nlm.nih.gov/pubmed/7530240
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02915.x
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author Washimi, Osuke
Ueda, Ryuzo
Ariyoshi, Yutaka
Suyama, Mot okazu
Seki, Tsuneo
Takahashi, Toshitada
Takahashi, Takashi
author_facet Washimi, Osuke
Ueda, Ryuzo
Ariyoshi, Yutaka
Suyama, Mot okazu
Seki, Tsuneo
Takahashi, Toshitada
Takahashi, Takashi
author_sort Washimi, Osuke
collection PubMed
description CD44 is a cell surface receptor that has been implicated in lymphocyte homing, hematopoiesis, cell migration and possibly also tumor metastasis. In the present study, expression of CD44 variant (CD44v) isoforms was analyzed in 23 lung cancer specimens together with corresponding normal lung tissues by Southern blot analysis coupled with reverse transcription‐polynterase chain reaction amplification. We found that CD44v isoforms were expressed in all lung cancer specimens, suggesting a possible role in the establishment of metastases by these highly malignant tumors, but normal tissues were also positive. This is in marked contrast to the previous reports of essentially negligible expression of CD44v isoforms in normal colon and breast, and suggests a physiological function in the lung.
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spelling pubmed-59193602018-05-11 Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung Washimi, Osuke Ueda, Ryuzo Ariyoshi, Yutaka Suyama, Mot okazu Seki, Tsuneo Takahashi, Toshitada Takahashi, Takashi Jpn J Cancer Res Article CD44 is a cell surface receptor that has been implicated in lymphocyte homing, hematopoiesis, cell migration and possibly also tumor metastasis. In the present study, expression of CD44 variant (CD44v) isoforms was analyzed in 23 lung cancer specimens together with corresponding normal lung tissues by Southern blot analysis coupled with reverse transcription‐polynterase chain reaction amplification. We found that CD44v isoforms were expressed in all lung cancer specimens, suggesting a possible role in the establishment of metastases by these highly malignant tumors, but normal tissues were also positive. This is in marked contrast to the previous reports of essentially negligible expression of CD44v isoforms in normal colon and breast, and suggests a physiological function in the lung. Blackwell Publishing Ltd 1994-11 /pmc/articles/PMC5919360/ /pubmed/7530240 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02915.x Text en
spellingShingle Article
Washimi, Osuke
Ueda, Ryuzo
Ariyoshi, Yutaka
Suyama, Mot okazu
Seki, Tsuneo
Takahashi, Toshitada
Takahashi, Takashi
Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung
title Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung
title_full Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung
title_fullStr Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung
title_full_unstemmed Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung
title_short Expression of CD44 Variant Isoforms in Normal and Neoplastic Cells of the Lung
title_sort expression of cd44 variant isoforms in normal and neoplastic cells of the lung
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919360/
https://www.ncbi.nlm.nih.gov/pubmed/7530240
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02915.x
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