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Intravenous Administration of Polyethylene Glycol‐modified Tumor Necrosis Factor‐α Completely Regressed Solid Tumor in Meth‐A Murine Sarcoma Model
Complete regression of solid tumors was achieved by plural intravenous (i.v.) administrations of polyethylene glycol (PEG)‐modified tumor necrosis factor‐a (TNF‐α), prepared by covalently modifying natural human TNF‐α with N‐succinimidyl succinate PEG. The anti‐tumor efficacy of PEG‐modifled TNF‐α (...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1994
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919383/ https://www.ncbi.nlm.nih.gov/pubmed/7852179 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02926.x |