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Intravenous Administration of Polyethylene Glycol‐modified Tumor Necrosis Factor‐α Completely Regressed Solid Tumor in Meth‐A Murine Sarcoma Model

Complete regression of solid tumors was achieved by plural intravenous (i.v.) administrations of polyethylene glycol (PEG)‐modified tumor necrosis factor‐a (TNF‐α), prepared by covalently modifying natural human TNF‐α with N‐succinimidyl succinate PEG. The anti‐tumor efficacy of PEG‐modifled TNF‐α (...

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Detalles Bibliográficos
Autores principales:	Tsutsumi, Yasuo, Kihira, Tetsunari, Tsunoda, Shin‐ichi, Kubo, Kazuyoshi, Miyake, Masaharu, Kanamori, Toshhiori, Nakagawa, Shinsaku, Mayumi, Tadanori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1994
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919383/ https://www.ncbi.nlm.nih.gov/pubmed/7852179 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02926.x

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