High Frequency of Cancer Patients with Abnormal Assembly of the T Cell Receptor‐CD3 Complex in Peripheral Blood T Lymphocytes

Structural abnormality of T cell receptor (TCR)‐CD3 complex on the cell surface was investigated in peripheral blood lymphocytes (PBL) from 55 cancer patients. In 24 of the 68 tests done on these patients, the CD3C chain was not detected by immunoprecipitation with anti‐CD3ζ monoclonal antibody (mAb...

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Detalles Bibliográficos
Autores principales: Gunji, Yoshio, Hori, Seiji, Aoe, Tomohiko, Asano, Takehide, Ochiai, Takenori, Isono, Kaichi, Saito, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919393/
https://www.ncbi.nlm.nih.gov/pubmed/7852180
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02927.x
Descripción
Sumario:Structural abnormality of T cell receptor (TCR)‐CD3 complex on the cell surface was investigated in peripheral blood lymphocytes (PBL) from 55 cancer patients. In 24 of the 68 tests done on these patients, the CD3C chain was not detected by immunoprecipitation with anti‐CD3ζ monoclonal antibody (mAb), but was observed with anti‐CD3ζ mAb, suggesting that a high frequency of cancer patients possesses abnormal T cell receptor (TCR) complex in PBL. On the other hand, the total ζ chain was missing in several advanced cases. During follow‐up of several patients, the ζ chain became undetectable after two or three months of cancer progression. It appears that immunosuppressive status can be monitored by analyzing the TCR‐CD3 complex on the cell surface of PBL.

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