Expression of cripto in Human Pancreatic Tumors
The expression of cripto gene product was examined immunohistochemically in 45 surgically resected pancreatic tumors, including 32 invasive ductal carcinomas, 4 intraductal papillary adenocarcinomas, 4 intraductal papillary adenomas, 2 mucinous cystadenomas, 2 islet cell tumors, and one solid and cy...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1994
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919414/ https://www.ncbi.nlm.nih.gov/pubmed/8144392 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02069.x |
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author | Tsutsumi, Masahiro Yasui, Wataru Naito, Azusa Ohashi, Kazuo Kobayashi, Eisaku Noguchi, Osamu Horiguchi, Kohsuke Okita, Shunji Tsujiuchi, Toshifumi Kitada, Hiromichi Ishikawa, Osamu Tahara, Eiichi Konishi, Yoichi |
author_facet | Tsutsumi, Masahiro Yasui, Wataru Naito, Azusa Ohashi, Kazuo Kobayashi, Eisaku Noguchi, Osamu Horiguchi, Kohsuke Okita, Shunji Tsujiuchi, Toshifumi Kitada, Hiromichi Ishikawa, Osamu Tahara, Eiichi Konishi, Yoichi |
author_sort | Tsutsumi, Masahiro |
collection | PubMed |
description | The expression of cripto gene product was examined immunohistochemically in 45 surgically resected pancreatic tumors, including 32 invasive ductal carcinomas, 4 intraductal papillary adenocarcinomas, 4 intraductal papillary adenomas, 2 mucinous cystadenomas, 2 islet cell tumors, and one solid and cystic tumor, and compared with that in 32 areas of accompanying chronic pancreatitis present in the cases of invasive ductal carcinomas and 5 non‐tumorous areas of pancreas without pancreatitis. All pancreatic ductal tumors including adenomas and carcinomas showed positive staining with no difference in terms of staining intensity among intraductal tumors and invasive carcinomas with or without mucin hypersecretion. Islet cell tumors were positively stained but the solid and cystic tumor was negative. Duct epithelial cells and acinar cells were negative but islet cells were positive in the pancreas tissues without pancreatitis. Cells arranged in duct‐like structures in areas of accompanying chronic pancreatitis were positively stained. The results suggest that cripto expression might be associated with a growth advantage of tumor cells and also with differentiation to form duct‐like structures. |
format | Online Article Text |
id | pubmed-5919414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1994 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59194142018-05-11 Expression of cripto in Human Pancreatic Tumors Tsutsumi, Masahiro Yasui, Wataru Naito, Azusa Ohashi, Kazuo Kobayashi, Eisaku Noguchi, Osamu Horiguchi, Kohsuke Okita, Shunji Tsujiuchi, Toshifumi Kitada, Hiromichi Ishikawa, Osamu Tahara, Eiichi Konishi, Yoichi Jpn J Cancer Res Rapid Communication The expression of cripto gene product was examined immunohistochemically in 45 surgically resected pancreatic tumors, including 32 invasive ductal carcinomas, 4 intraductal papillary adenocarcinomas, 4 intraductal papillary adenomas, 2 mucinous cystadenomas, 2 islet cell tumors, and one solid and cystic tumor, and compared with that in 32 areas of accompanying chronic pancreatitis present in the cases of invasive ductal carcinomas and 5 non‐tumorous areas of pancreas without pancreatitis. All pancreatic ductal tumors including adenomas and carcinomas showed positive staining with no difference in terms of staining intensity among intraductal tumors and invasive carcinomas with or without mucin hypersecretion. Islet cell tumors were positively stained but the solid and cystic tumor was negative. Duct epithelial cells and acinar cells were negative but islet cells were positive in the pancreas tissues without pancreatitis. Cells arranged in duct‐like structures in areas of accompanying chronic pancreatitis were positively stained. The results suggest that cripto expression might be associated with a growth advantage of tumor cells and also with differentiation to form duct‐like structures. Blackwell Publishing Ltd 1994-02 /pmc/articles/PMC5919414/ /pubmed/8144392 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02069.x Text en |
spellingShingle | Rapid Communication Tsutsumi, Masahiro Yasui, Wataru Naito, Azusa Ohashi, Kazuo Kobayashi, Eisaku Noguchi, Osamu Horiguchi, Kohsuke Okita, Shunji Tsujiuchi, Toshifumi Kitada, Hiromichi Ishikawa, Osamu Tahara, Eiichi Konishi, Yoichi Expression of cripto in Human Pancreatic Tumors |
title | Expression of cripto in Human Pancreatic Tumors |
title_full | Expression of cripto in Human Pancreatic Tumors |
title_fullStr | Expression of cripto in Human Pancreatic Tumors |
title_full_unstemmed | Expression of cripto in Human Pancreatic Tumors |
title_short | Expression of cripto in Human Pancreatic Tumors |
title_sort | expression of cripto in human pancreatic tumors |
topic | Rapid Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919414/ https://www.ncbi.nlm.nih.gov/pubmed/8144392 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02069.x |
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