Expression of cripto in Human Pancreatic Tumors

The expression of cripto gene product was examined immunohistochemically in 45 surgically resected pancreatic tumors, including 32 invasive ductal carcinomas, 4 intraductal papillary adenocarcinomas, 4 intraductal papillary adenomas, 2 mucinous cystadenomas, 2 islet cell tumors, and one solid and cy...

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Autores principales: Tsutsumi, Masahiro, Yasui, Wataru, Naito, Azusa, Ohashi, Kazuo, Kobayashi, Eisaku, Noguchi, Osamu, Horiguchi, Kohsuke, Okita, Shunji, Tsujiuchi, Toshifumi, Kitada, Hiromichi, Ishikawa, Osamu, Tahara, Eiichi, Konishi, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919414/
https://www.ncbi.nlm.nih.gov/pubmed/8144392
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02069.x
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author Tsutsumi, Masahiro
Yasui, Wataru
Naito, Azusa
Ohashi, Kazuo
Kobayashi, Eisaku
Noguchi, Osamu
Horiguchi, Kohsuke
Okita, Shunji
Tsujiuchi, Toshifumi
Kitada, Hiromichi
Ishikawa, Osamu
Tahara, Eiichi
Konishi, Yoichi
author_facet Tsutsumi, Masahiro
Yasui, Wataru
Naito, Azusa
Ohashi, Kazuo
Kobayashi, Eisaku
Noguchi, Osamu
Horiguchi, Kohsuke
Okita, Shunji
Tsujiuchi, Toshifumi
Kitada, Hiromichi
Ishikawa, Osamu
Tahara, Eiichi
Konishi, Yoichi
author_sort Tsutsumi, Masahiro
collection PubMed
description The expression of cripto gene product was examined immunohistochemically in 45 surgically resected pancreatic tumors, including 32 invasive ductal carcinomas, 4 intraductal papillary adenocarcinomas, 4 intraductal papillary adenomas, 2 mucinous cystadenomas, 2 islet cell tumors, and one solid and cystic tumor, and compared with that in 32 areas of accompanying chronic pancreatitis present in the cases of invasive ductal carcinomas and 5 non‐tumorous areas of pancreas without pancreatitis. All pancreatic ductal tumors including adenomas and carcinomas showed positive staining with no difference in terms of staining intensity among intraductal tumors and invasive carcinomas with or without mucin hypersecretion. Islet cell tumors were positively stained but the solid and cystic tumor was negative. Duct epithelial cells and acinar cells were negative but islet cells were positive in the pancreas tissues without pancreatitis. Cells arranged in duct‐like structures in areas of accompanying chronic pancreatitis were positively stained. The results suggest that cripto expression might be associated with a growth advantage of tumor cells and also with differentiation to form duct‐like structures.
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spelling pubmed-59194142018-05-11 Expression of cripto in Human Pancreatic Tumors Tsutsumi, Masahiro Yasui, Wataru Naito, Azusa Ohashi, Kazuo Kobayashi, Eisaku Noguchi, Osamu Horiguchi, Kohsuke Okita, Shunji Tsujiuchi, Toshifumi Kitada, Hiromichi Ishikawa, Osamu Tahara, Eiichi Konishi, Yoichi Jpn J Cancer Res Rapid Communication The expression of cripto gene product was examined immunohistochemically in 45 surgically resected pancreatic tumors, including 32 invasive ductal carcinomas, 4 intraductal papillary adenocarcinomas, 4 intraductal papillary adenomas, 2 mucinous cystadenomas, 2 islet cell tumors, and one solid and cystic tumor, and compared with that in 32 areas of accompanying chronic pancreatitis present in the cases of invasive ductal carcinomas and 5 non‐tumorous areas of pancreas without pancreatitis. All pancreatic ductal tumors including adenomas and carcinomas showed positive staining with no difference in terms of staining intensity among intraductal tumors and invasive carcinomas with or without mucin hypersecretion. Islet cell tumors were positively stained but the solid and cystic tumor was negative. Duct epithelial cells and acinar cells were negative but islet cells were positive in the pancreas tissues without pancreatitis. Cells arranged in duct‐like structures in areas of accompanying chronic pancreatitis were positively stained. The results suggest that cripto expression might be associated with a growth advantage of tumor cells and also with differentiation to form duct‐like structures. Blackwell Publishing Ltd 1994-02 /pmc/articles/PMC5919414/ /pubmed/8144392 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02069.x Text en
spellingShingle Rapid Communication
Tsutsumi, Masahiro
Yasui, Wataru
Naito, Azusa
Ohashi, Kazuo
Kobayashi, Eisaku
Noguchi, Osamu
Horiguchi, Kohsuke
Okita, Shunji
Tsujiuchi, Toshifumi
Kitada, Hiromichi
Ishikawa, Osamu
Tahara, Eiichi
Konishi, Yoichi
Expression of cripto in Human Pancreatic Tumors
title Expression of cripto in Human Pancreatic Tumors
title_full Expression of cripto in Human Pancreatic Tumors
title_fullStr Expression of cripto in Human Pancreatic Tumors
title_full_unstemmed Expression of cripto in Human Pancreatic Tumors
title_short Expression of cripto in Human Pancreatic Tumors
title_sort expression of cripto in human pancreatic tumors
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919414/
https://www.ncbi.nlm.nih.gov/pubmed/8144392
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02069.x
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