Increased Expression of trk Proto‐oncogene by γ‐Interferon in Human Neuroblastoma Cell Lines

Three human neuroblastoma cell lines were examined to determine the effect of recombinant γ‐interferon (IFN‐γ) treatment on the expression of trk proto‐oncogene. Increased levels of trk proto‐oncogene mRNA were observed in two neuroblastoma cell lines (KP‐N‐RT and KP‐N‐SI(FA)) after IFN‐γ treatment....

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Detalles Bibliográficos
Autores principales: Shikata, Akane, Sugimoto, Tohru, Hosoi, Hajime, Sotozono, Yasuhiro, Shikata, Takuma, Sawada, Tadashi, Parada, Luis F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919423/
https://www.ncbi.nlm.nih.gov/pubmed/8144393
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02070.x
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author Shikata, Akane
Sugimoto, Tohru
Hosoi, Hajime
Sotozono, Yasuhiro
Shikata, Takuma
Sawada, Tadashi
Parada, Luis F.
author_facet Shikata, Akane
Sugimoto, Tohru
Hosoi, Hajime
Sotozono, Yasuhiro
Shikata, Takuma
Sawada, Tadashi
Parada, Luis F.
author_sort Shikata, Akane
collection PubMed
description Three human neuroblastoma cell lines were examined to determine the effect of recombinant γ‐interferon (IFN‐γ) treatment on the expression of trk proto‐oncogene. Increased levels of trk proto‐oncogene mRNA were observed in two neuroblastoma cell lines (KP‐N‐RT and KP‐N‐SI(FA)) after IFN‐γ treatment. The levels of trk mRNA increased with growth inhibition and morphological change in a time‐ and dose‐dependent manner. The decreased level of N‐myc mRNA after IFN‐γ‐treatment in KP‐N‐RT was inversely correlated with trk mRNA. Our results suggest that IFN‐γ can modulate the signal transduction of nerve growth factor in human neuroblastoma cells.
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spelling pubmed-59194232018-05-11 Increased Expression of trk Proto‐oncogene by γ‐Interferon in Human Neuroblastoma Cell Lines Shikata, Akane Sugimoto, Tohru Hosoi, Hajime Sotozono, Yasuhiro Shikata, Takuma Sawada, Tadashi Parada, Luis F. Jpn J Cancer Res Rapid Communication Three human neuroblastoma cell lines were examined to determine the effect of recombinant γ‐interferon (IFN‐γ) treatment on the expression of trk proto‐oncogene. Increased levels of trk proto‐oncogene mRNA were observed in two neuroblastoma cell lines (KP‐N‐RT and KP‐N‐SI(FA)) after IFN‐γ treatment. The levels of trk mRNA increased with growth inhibition and morphological change in a time‐ and dose‐dependent manner. The decreased level of N‐myc mRNA after IFN‐γ‐treatment in KP‐N‐RT was inversely correlated with trk mRNA. Our results suggest that IFN‐γ can modulate the signal transduction of nerve growth factor in human neuroblastoma cells. Blackwell Publishing Ltd 1994-02 /pmc/articles/PMC5919423/ /pubmed/8144393 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02070.x Text en
spellingShingle Rapid Communication
Shikata, Akane
Sugimoto, Tohru
Hosoi, Hajime
Sotozono, Yasuhiro
Shikata, Takuma
Sawada, Tadashi
Parada, Luis F.
Increased Expression of trk Proto‐oncogene by γ‐Interferon in Human Neuroblastoma Cell Lines
title Increased Expression of trk Proto‐oncogene by γ‐Interferon in Human Neuroblastoma Cell Lines
title_full Increased Expression of trk Proto‐oncogene by γ‐Interferon in Human Neuroblastoma Cell Lines
title_fullStr Increased Expression of trk Proto‐oncogene by γ‐Interferon in Human Neuroblastoma Cell Lines
title_full_unstemmed Increased Expression of trk Proto‐oncogene by γ‐Interferon in Human Neuroblastoma Cell Lines
title_short Increased Expression of trk Proto‐oncogene by γ‐Interferon in Human Neuroblastoma Cell Lines
title_sort increased expression of trk proto‐oncogene by γ‐interferon in human neuroblastoma cell lines
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919423/
https://www.ncbi.nlm.nih.gov/pubmed/8144393
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02070.x
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