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Detection of Guanine‐C8‐2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine Adduct as a Single Spot on Thin‐layer Chromatography by Modification of the (32)P‐Postlabeling Method

N‐(Deoxyguanosin‐8‐yl)‐2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (dG‐C8‐PhIP) has been shown to be a major adduct in DNA of rats given [(3)H]PhIP. However, when DNA from organs of rats fed PhIP was analyzed by the (32)P‐postlabeling method under standard and adduct‐intensification conditions,...

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Detalles Bibliográficos
Autores principales: Fukutome, Kazuo, Ochiai, Masako, Wakabayashi, Keiji, Watanabe, Shinya, Sugimura, Takashi, Nagao, Minako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919426/
https://www.ncbi.nlm.nih.gov/pubmed/8144391
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02068.x

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