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Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease
Parkinson’s disease (PD) is known to increase asymmetry and variability of bilateral movements. However, the mechanisms of such abnormalities are not fully understood. Here, we aimed to investigate whether kinematic abnormalities are related to cortical participation during bilateral, cyclical ankle...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919457/ https://www.ncbi.nlm.nih.gov/pubmed/29698430 http://dx.doi.org/10.1371/journal.pone.0196177 |
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author | Yoshida, Takashi Masani, Kei Zabjek, Karl Popovic, Milos R. Chen, Robert |
author_facet | Yoshida, Takashi Masani, Kei Zabjek, Karl Popovic, Milos R. Chen, Robert |
author_sort | Yoshida, Takashi |
collection | PubMed |
description | Parkinson’s disease (PD) is known to increase asymmetry and variability of bilateral movements. However, the mechanisms of such abnormalities are not fully understood. Here, we aimed to investigate whether kinematic abnormalities are related to cortical participation during bilateral, cyclical ankle movements, which required i) maintenance of a specific frequency and ii) bilateral coordination of the lower limbs in an anti-phasic manner. We analyzed electroencephalographic and electromyographic signals from nine men with PD and nine aged-matched healthy men while they sat and cyclically dorsi- and plantarflexed their feet. This movement was performed at a similar cadence to normal walking under two conditions: i) self-paced and ii) externally paced by a metronome. Participants with PD exhibited reduced range of motion and more variable bilateral coordination. However, participants with and without PD did not differ in the magnitude of corticomuscular coherence between the midline cortical areas and tibialis anterior and medial gastrocnemius muscles. This finding suggests that either the kinematic abnormalities were related to processes outside linear corticomuscular communication or PD-related changes in neural correlates maintained corticomuscular communication but not motor performance. |
format | Online Article Text |
id | pubmed-5919457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-59194572018-05-11 Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease Yoshida, Takashi Masani, Kei Zabjek, Karl Popovic, Milos R. Chen, Robert PLoS One Research Article Parkinson’s disease (PD) is known to increase asymmetry and variability of bilateral movements. However, the mechanisms of such abnormalities are not fully understood. Here, we aimed to investigate whether kinematic abnormalities are related to cortical participation during bilateral, cyclical ankle movements, which required i) maintenance of a specific frequency and ii) bilateral coordination of the lower limbs in an anti-phasic manner. We analyzed electroencephalographic and electromyographic signals from nine men with PD and nine aged-matched healthy men while they sat and cyclically dorsi- and plantarflexed their feet. This movement was performed at a similar cadence to normal walking under two conditions: i) self-paced and ii) externally paced by a metronome. Participants with PD exhibited reduced range of motion and more variable bilateral coordination. However, participants with and without PD did not differ in the magnitude of corticomuscular coherence between the midline cortical areas and tibialis anterior and medial gastrocnemius muscles. This finding suggests that either the kinematic abnormalities were related to processes outside linear corticomuscular communication or PD-related changes in neural correlates maintained corticomuscular communication but not motor performance. Public Library of Science 2018-04-26 /pmc/articles/PMC5919457/ /pubmed/29698430 http://dx.doi.org/10.1371/journal.pone.0196177 Text en © 2018 Yoshida et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Yoshida, Takashi Masani, Kei Zabjek, Karl Popovic, Milos R. Chen, Robert Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease |
title | Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease |
title_full | Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease |
title_fullStr | Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease |
title_full_unstemmed | Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease |
title_short | Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease |
title_sort | dynamic cortical participation during bilateral, cyclical ankle movements: effects of parkinson’s disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919457/ https://www.ncbi.nlm.nih.gov/pubmed/29698430 http://dx.doi.org/10.1371/journal.pone.0196177 |
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