Cargando…

Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease

Parkinson’s disease (PD) is known to increase asymmetry and variability of bilateral movements. However, the mechanisms of such abnormalities are not fully understood. Here, we aimed to investigate whether kinematic abnormalities are related to cortical participation during bilateral, cyclical ankle...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshida, Takashi, Masani, Kei, Zabjek, Karl, Popovic, Milos R., Chen, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919457/
https://www.ncbi.nlm.nih.gov/pubmed/29698430
http://dx.doi.org/10.1371/journal.pone.0196177
_version_ 1783317631015583744
author Yoshida, Takashi
Masani, Kei
Zabjek, Karl
Popovic, Milos R.
Chen, Robert
author_facet Yoshida, Takashi
Masani, Kei
Zabjek, Karl
Popovic, Milos R.
Chen, Robert
author_sort Yoshida, Takashi
collection PubMed
description Parkinson’s disease (PD) is known to increase asymmetry and variability of bilateral movements. However, the mechanisms of such abnormalities are not fully understood. Here, we aimed to investigate whether kinematic abnormalities are related to cortical participation during bilateral, cyclical ankle movements, which required i) maintenance of a specific frequency and ii) bilateral coordination of the lower limbs in an anti-phasic manner. We analyzed electroencephalographic and electromyographic signals from nine men with PD and nine aged-matched healthy men while they sat and cyclically dorsi- and plantarflexed their feet. This movement was performed at a similar cadence to normal walking under two conditions: i) self-paced and ii) externally paced by a metronome. Participants with PD exhibited reduced range of motion and more variable bilateral coordination. However, participants with and without PD did not differ in the magnitude of corticomuscular coherence between the midline cortical areas and tibialis anterior and medial gastrocnemius muscles. This finding suggests that either the kinematic abnormalities were related to processes outside linear corticomuscular communication or PD-related changes in neural correlates maintained corticomuscular communication but not motor performance.
format Online
Article
Text
id pubmed-5919457
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-59194572018-05-11 Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease Yoshida, Takashi Masani, Kei Zabjek, Karl Popovic, Milos R. Chen, Robert PLoS One Research Article Parkinson’s disease (PD) is known to increase asymmetry and variability of bilateral movements. However, the mechanisms of such abnormalities are not fully understood. Here, we aimed to investigate whether kinematic abnormalities are related to cortical participation during bilateral, cyclical ankle movements, which required i) maintenance of a specific frequency and ii) bilateral coordination of the lower limbs in an anti-phasic manner. We analyzed electroencephalographic and electromyographic signals from nine men with PD and nine aged-matched healthy men while they sat and cyclically dorsi- and plantarflexed their feet. This movement was performed at a similar cadence to normal walking under two conditions: i) self-paced and ii) externally paced by a metronome. Participants with PD exhibited reduced range of motion and more variable bilateral coordination. However, participants with and without PD did not differ in the magnitude of corticomuscular coherence between the midline cortical areas and tibialis anterior and medial gastrocnemius muscles. This finding suggests that either the kinematic abnormalities were related to processes outside linear corticomuscular communication or PD-related changes in neural correlates maintained corticomuscular communication but not motor performance. Public Library of Science 2018-04-26 /pmc/articles/PMC5919457/ /pubmed/29698430 http://dx.doi.org/10.1371/journal.pone.0196177 Text en © 2018 Yoshida et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yoshida, Takashi
Masani, Kei
Zabjek, Karl
Popovic, Milos R.
Chen, Robert
Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease
title Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease
title_full Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease
title_fullStr Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease
title_full_unstemmed Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease
title_short Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson’s disease
title_sort dynamic cortical participation during bilateral, cyclical ankle movements: effects of parkinson’s disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919457/
https://www.ncbi.nlm.nih.gov/pubmed/29698430
http://dx.doi.org/10.1371/journal.pone.0196177
work_keys_str_mv AT yoshidatakashi dynamiccorticalparticipationduringbilateralcyclicalanklemovementseffectsofparkinsonsdisease
AT masanikei dynamiccorticalparticipationduringbilateralcyclicalanklemovementseffectsofparkinsonsdisease
AT zabjekkarl dynamiccorticalparticipationduringbilateralcyclicalanklemovementseffectsofparkinsonsdisease
AT popovicmilosr dynamiccorticalparticipationduringbilateralcyclicalanklemovementseffectsofparkinsonsdisease
AT chenrobert dynamiccorticalparticipationduringbilateralcyclicalanklemovementseffectsofparkinsonsdisease