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Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis

Lethal midline granuloma (LMG) is a clinical term used to describe a condition which may be manifested histologically as Wegener's granulomatosis (WG), polymorphic reticulosis (PR), and malignant lymphoma (ML). WG is an inflammatory disease, and PR and ML are considered to represent a neoplasti...

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Autores principales: Kojya, Shizuo, Itokazu, Tetsuo, Maeshiro, Norihide, Esu, Hiroaki, Noda, Yutaka, Mishima, Kenji, Ohsawa, Masahiko, Aozasa, Katsuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919472/
https://www.ncbi.nlm.nih.gov/pubmed/8200852
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02371.x
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author Kojya, Shizuo
Itokazu, Tetsuo
Maeshiro, Norihide
Esu, Hiroaki
Noda, Yutaka
Mishima, Kenji
Ohsawa, Masahiko
Aozasa, Katsuyuki
author_facet Kojya, Shizuo
Itokazu, Tetsuo
Maeshiro, Norihide
Esu, Hiroaki
Noda, Yutaka
Mishima, Kenji
Ohsawa, Masahiko
Aozasa, Katsuyuki
author_sort Kojya, Shizuo
collection PubMed
description Lethal midline granuloma (LMG) is a clinical term used to describe a condition which may be manifested histologically as Wegener's granulomatosis (WG), polymorphic reticulosis (PR), and malignant lymphoma (ML). WG is an inflammatory disease, and PR and ML are considered to represent a neoplastic proliferation of lymphoreticular cells. In this report, twenty‐two cases of LMG in Okinawa were examined. The frequency of LMG per 100,000 outpatients of the ear, nose and throat clinic in Okinawa was 67, and the higher frequency of PR (27) and ML (34) in Okinawa than in other districts of Japan was characteristic. Polymerase chain reaction, in situ hybridization, and immunohistochemical studies showed that the proliferating cells in PR were CD43(+) and simultaneously contained Epstein‐Barr viral genome in their nuclei. The higher frequency of PR and ML in Okinawa is discussed in conjunction with a review of pertinent literature: multiple factors including genetic, viral environmental, and socioeconomic factors seem to affect the frequencies of these diseases.
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spelling pubmed-59194722018-05-11 Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis Kojya, Shizuo Itokazu, Tetsuo Maeshiro, Norihide Esu, Hiroaki Noda, Yutaka Mishima, Kenji Ohsawa, Masahiko Aozasa, Katsuyuki Jpn J Cancer Res Article Lethal midline granuloma (LMG) is a clinical term used to describe a condition which may be manifested histologically as Wegener's granulomatosis (WG), polymorphic reticulosis (PR), and malignant lymphoma (ML). WG is an inflammatory disease, and PR and ML are considered to represent a neoplastic proliferation of lymphoreticular cells. In this report, twenty‐two cases of LMG in Okinawa were examined. The frequency of LMG per 100,000 outpatients of the ear, nose and throat clinic in Okinawa was 67, and the higher frequency of PR (27) and ML (34) in Okinawa than in other districts of Japan was characteristic. Polymerase chain reaction, in situ hybridization, and immunohistochemical studies showed that the proliferating cells in PR were CD43(+) and simultaneously contained Epstein‐Barr viral genome in their nuclei. The higher frequency of PR and ML in Okinawa is discussed in conjunction with a review of pertinent literature: multiple factors including genetic, viral environmental, and socioeconomic factors seem to affect the frequencies of these diseases. Blackwell Publishing Ltd 1994-04 /pmc/articles/PMC5919472/ /pubmed/8200852 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02371.x Text en
spellingShingle Article
Kojya, Shizuo
Itokazu, Tetsuo
Maeshiro, Norihide
Esu, Hiroaki
Noda, Yutaka
Mishima, Kenji
Ohsawa, Masahiko
Aozasa, Katsuyuki
Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis
title Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis
title_full Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis
title_fullStr Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis
title_full_unstemmed Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis
title_short Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis
title_sort lethal midline granuloma in okinawa with special emphasis on polymorphic reticulosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919472/
https://www.ncbi.nlm.nih.gov/pubmed/8200852
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02371.x
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