Cargando…
Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis
Lethal midline granuloma (LMG) is a clinical term used to describe a condition which may be manifested histologically as Wegener's granulomatosis (WG), polymorphic reticulosis (PR), and malignant lymphoma (ML). WG is an inflammatory disease, and PR and ML are considered to represent a neoplasti...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1994
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919472/ https://www.ncbi.nlm.nih.gov/pubmed/8200852 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02371.x |
_version_ | 1783317634520973312 |
---|---|
author | Kojya, Shizuo Itokazu, Tetsuo Maeshiro, Norihide Esu, Hiroaki Noda, Yutaka Mishima, Kenji Ohsawa, Masahiko Aozasa, Katsuyuki |
author_facet | Kojya, Shizuo Itokazu, Tetsuo Maeshiro, Norihide Esu, Hiroaki Noda, Yutaka Mishima, Kenji Ohsawa, Masahiko Aozasa, Katsuyuki |
author_sort | Kojya, Shizuo |
collection | PubMed |
description | Lethal midline granuloma (LMG) is a clinical term used to describe a condition which may be manifested histologically as Wegener's granulomatosis (WG), polymorphic reticulosis (PR), and malignant lymphoma (ML). WG is an inflammatory disease, and PR and ML are considered to represent a neoplastic proliferation of lymphoreticular cells. In this report, twenty‐two cases of LMG in Okinawa were examined. The frequency of LMG per 100,000 outpatients of the ear, nose and throat clinic in Okinawa was 67, and the higher frequency of PR (27) and ML (34) in Okinawa than in other districts of Japan was characteristic. Polymerase chain reaction, in situ hybridization, and immunohistochemical studies showed that the proliferating cells in PR were CD43(+) and simultaneously contained Epstein‐Barr viral genome in their nuclei. The higher frequency of PR and ML in Okinawa is discussed in conjunction with a review of pertinent literature: multiple factors including genetic, viral environmental, and socioeconomic factors seem to affect the frequencies of these diseases. |
format | Online Article Text |
id | pubmed-5919472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1994 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59194722018-05-11 Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis Kojya, Shizuo Itokazu, Tetsuo Maeshiro, Norihide Esu, Hiroaki Noda, Yutaka Mishima, Kenji Ohsawa, Masahiko Aozasa, Katsuyuki Jpn J Cancer Res Article Lethal midline granuloma (LMG) is a clinical term used to describe a condition which may be manifested histologically as Wegener's granulomatosis (WG), polymorphic reticulosis (PR), and malignant lymphoma (ML). WG is an inflammatory disease, and PR and ML are considered to represent a neoplastic proliferation of lymphoreticular cells. In this report, twenty‐two cases of LMG in Okinawa were examined. The frequency of LMG per 100,000 outpatients of the ear, nose and throat clinic in Okinawa was 67, and the higher frequency of PR (27) and ML (34) in Okinawa than in other districts of Japan was characteristic. Polymerase chain reaction, in situ hybridization, and immunohistochemical studies showed that the proliferating cells in PR were CD43(+) and simultaneously contained Epstein‐Barr viral genome in their nuclei. The higher frequency of PR and ML in Okinawa is discussed in conjunction with a review of pertinent literature: multiple factors including genetic, viral environmental, and socioeconomic factors seem to affect the frequencies of these diseases. Blackwell Publishing Ltd 1994-04 /pmc/articles/PMC5919472/ /pubmed/8200852 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02371.x Text en |
spellingShingle | Article Kojya, Shizuo Itokazu, Tetsuo Maeshiro, Norihide Esu, Hiroaki Noda, Yutaka Mishima, Kenji Ohsawa, Masahiko Aozasa, Katsuyuki Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis |
title | Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis |
title_full | Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis |
title_fullStr | Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis |
title_full_unstemmed | Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis |
title_short | Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis |
title_sort | lethal midline granuloma in okinawa with special emphasis on polymorphic reticulosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919472/ https://www.ncbi.nlm.nih.gov/pubmed/8200852 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02371.x |
work_keys_str_mv | AT kojyashizuo lethalmidlinegranulomainokinawawithspecialemphasisonpolymorphicreticulosis AT itokazutetsuo lethalmidlinegranulomainokinawawithspecialemphasisonpolymorphicreticulosis AT maeshironorihide lethalmidlinegranulomainokinawawithspecialemphasisonpolymorphicreticulosis AT esuhiroaki lethalmidlinegranulomainokinawawithspecialemphasisonpolymorphicreticulosis AT nodayutaka lethalmidlinegranulomainokinawawithspecialemphasisonpolymorphicreticulosis AT mishimakenji lethalmidlinegranulomainokinawawithspecialemphasisonpolymorphicreticulosis AT ohsawamasahiko lethalmidlinegranulomainokinawawithspecialemphasisonpolymorphicreticulosis AT aozasakatsuyuki lethalmidlinegranulomainokinawawithspecialemphasisonpolymorphicreticulosis |