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Inhibition of Topoisomerase II by a Novel Antitumor Cyclic Depsipeptide, BE‐22179

BE‐22179, a novel cyclic depsipeptide antibiotic having two 3‐hydroxyquinoline moieties, inhibited the DNA‐relaxing activity of L1210 topoisomerase II completely at 0.08 μM. This effect was far stronger than that of VP‐16. However, it did not show any marked effect on topoisomerase II‐mediated DNA c...

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Detalles Bibliográficos
Autores principales:	Yoshinari, Tomoko, Okada, Hiromasa, Yamada, Akihiro, Uemura, Daisuke, Oka, Hirofumi, Suda, Hiroyuki, Okura, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1994
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919495/ https://www.ncbi.nlm.nih.gov/pubmed/8014113 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02394.x

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