Spontaneous Renal Cell Tumors in Long‐Evans Cinnamon Rats

Neoplastic lesions of the kidneys in untreated Long‐Evans Cinnamon (LEC) rats of 57–118 weeks old (85 males and 34 females) and male F344 rats of 64–93 weeks old (59 males) were examined histologically. The incidences of renal cell tumors in male and female LEC rats were 6/80 (8%) in weeks 57–65, 3/...

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Detalles Bibliográficos
Autores principales: Izumi, Keisuke, Kitaura, Keisuke, Chone, Yoshifumi, Tate, Hideki, Nakagawa, Tateo, Suzuki, Yasuo, Matsumoto, Kozo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919523/
https://www.ncbi.nlm.nih.gov/pubmed/8063607
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02396.x
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author Izumi, Keisuke
Kitaura, Keisuke
Chone, Yoshifumi
Tate, Hideki
Nakagawa, Tateo
Suzuki, Yasuo
Matsumoto, Kozo
author_facet Izumi, Keisuke
Kitaura, Keisuke
Chone, Yoshifumi
Tate, Hideki
Nakagawa, Tateo
Suzuki, Yasuo
Matsumoto, Kozo
author_sort Izumi, Keisuke
collection PubMed
description Neoplastic lesions of the kidneys in untreated Long‐Evans Cinnamon (LEC) rats of 57–118 weeks old (85 males and 34 females) and male F344 rats of 64–93 weeks old (59 males) were examined histologically. The incidences of renal cell tumors in male and female LEC rats were 6/80 (8%) in weeks 57–65, 3/19 (16%) in weeks 66–75, 3/8 (38%) in weeks 76–105 and 7/12 (58%) in weeks 106–118. Of these tumors, 13 were microscopic adenomas and 7 were renal cell carcinomas. The copper content of the kidneys was about three times higher in LEC rats than in F344 rats (P<0.001), but the iron content of the kidneys was similar in the two strains.
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spelling pubmed-59195232018-05-11 Spontaneous Renal Cell Tumors in Long‐Evans Cinnamon Rats Izumi, Keisuke Kitaura, Keisuke Chone, Yoshifumi Tate, Hideki Nakagawa, Tateo Suzuki, Yasuo Matsumoto, Kozo Jpn J Cancer Res Rapid Communication Neoplastic lesions of the kidneys in untreated Long‐Evans Cinnamon (LEC) rats of 57–118 weeks old (85 males and 34 females) and male F344 rats of 64–93 weeks old (59 males) were examined histologically. The incidences of renal cell tumors in male and female LEC rats were 6/80 (8%) in weeks 57–65, 3/19 (16%) in weeks 66–75, 3/8 (38%) in weeks 76–105 and 7/12 (58%) in weeks 106–118. Of these tumors, 13 were microscopic adenomas and 7 were renal cell carcinomas. The copper content of the kidneys was about three times higher in LEC rats than in F344 rats (P<0.001), but the iron content of the kidneys was similar in the two strains. Blackwell Publishing Ltd 1994-06 /pmc/articles/PMC5919523/ /pubmed/8063607 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02396.x Text en
spellingShingle Rapid Communication
Izumi, Keisuke
Kitaura, Keisuke
Chone, Yoshifumi
Tate, Hideki
Nakagawa, Tateo
Suzuki, Yasuo
Matsumoto, Kozo
Spontaneous Renal Cell Tumors in Long‐Evans Cinnamon Rats
title Spontaneous Renal Cell Tumors in Long‐Evans Cinnamon Rats
title_full Spontaneous Renal Cell Tumors in Long‐Evans Cinnamon Rats
title_fullStr Spontaneous Renal Cell Tumors in Long‐Evans Cinnamon Rats
title_full_unstemmed Spontaneous Renal Cell Tumors in Long‐Evans Cinnamon Rats
title_short Spontaneous Renal Cell Tumors in Long‐Evans Cinnamon Rats
title_sort spontaneous renal cell tumors in long‐evans cinnamon rats
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919523/
https://www.ncbi.nlm.nih.gov/pubmed/8063607
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02396.x
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