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Cytotoxicity of Simvastatin to Pancreatic Adenocarcinoma Cells Containing Mutant ras Gene

Simvastatin (SV), a 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitor, inhibits the synthesis of mevalonic acid. The dose‐dependent (0.1–100 μg/ml) cytotoxicity of SV towards human (MIAPaCa‐2, Panc‐1, HPC‐1, HPC‐3, HPC‐4, PK‐1, PK‐9) and hamster (T2) pancreatic carcinoma cell lines was deter...

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Detalles Bibliográficos
Autores principales:	Ura, Hitoshi, Obara, Takeshi, Nishino, Noriyuki, Tanno, Satoshi, Okamura, Kiyoshi, Namiki, Masayoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1994
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919528/ https://www.ncbi.nlm.nih.gov/pubmed/8063617 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02406.x

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