Subtype Analysis of HTLV‐1 in Patients with HTLV‐1 Uveitis

The hypothesis that HTLV‐1 uveitis, a recently identified disease entity associated with human T‐cell leukemia virus type I (HTLV‐1), is caused by a specific subtype of the virus was tested. The nucleotide sequences of the long terminal repeat of HTLV‐1 from five patients with HTLV‐1 uveitis (HU) an...

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Detalles Bibliográficos
Autores principales: Ono, Ayako, Miura, Tomoyuki, Araki, Shinji, Yamaguchi, Kazunari, Takatsuki, Kiyoshi, Mori, Sigeo, Hayami, Masanori, Mochizuki, Manabu, Watanabe, Toshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919557/
https://www.ncbi.nlm.nih.gov/pubmed/7928620
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02945.x
Descripción
Sumario:The hypothesis that HTLV‐1 uveitis, a recently identified disease entity associated with human T‐cell leukemia virus type I (HTLV‐1), is caused by a specific subtype of the virus was tested. The nucleotide sequences of the long terminal repeat of HTLV‐1 from five patients with HTLV‐1 uveitis (HU) and four with adult T‐cell leukemia were phylogenetically analyzed. Our results showed that both subtypes which had been identified in Japan were associated with HU, indicating that there was no difference in pathogenicity between these phylogenetic subtypes. One of the subtypes was more frequently isolated in Okinawa than in Kyushu, suggesting a bias in the prevalence of each subtype among the inhabitants of these two areas of Japan.

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