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Subtype Analysis of HTLV‐1 in Patients with HTLV‐1 Uveitis
The hypothesis that HTLV‐1 uveitis, a recently identified disease entity associated with human T‐cell leukemia virus type I (HTLV‐1), is caused by a specific subtype of the virus was tested. The nucleotide sequences of the long terminal repeat of HTLV‐1 from five patients with HTLV‐1 uveitis (HU) an...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1994
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919557/ https://www.ncbi.nlm.nih.gov/pubmed/7928620 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02945.x |
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author | Ono, Ayako Miura, Tomoyuki Araki, Shinji Yamaguchi, Kazunari Takatsuki, Kiyoshi Mori, Sigeo Hayami, Masanori Mochizuki, Manabu Watanabe, Toshiki |
author_facet | Ono, Ayako Miura, Tomoyuki Araki, Shinji Yamaguchi, Kazunari Takatsuki, Kiyoshi Mori, Sigeo Hayami, Masanori Mochizuki, Manabu Watanabe, Toshiki |
author_sort | Ono, Ayako |
collection | PubMed |
description | The hypothesis that HTLV‐1 uveitis, a recently identified disease entity associated with human T‐cell leukemia virus type I (HTLV‐1), is caused by a specific subtype of the virus was tested. The nucleotide sequences of the long terminal repeat of HTLV‐1 from five patients with HTLV‐1 uveitis (HU) and four with adult T‐cell leukemia were phylogenetically analyzed. Our results showed that both subtypes which had been identified in Japan were associated with HU, indicating that there was no difference in pathogenicity between these phylogenetic subtypes. One of the subtypes was more frequently isolated in Okinawa than in Kyushu, suggesting a bias in the prevalence of each subtype among the inhabitants of these two areas of Japan. |
format | Online Article Text |
id | pubmed-5919557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1994 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59195572018-05-11 Subtype Analysis of HTLV‐1 in Patients with HTLV‐1 Uveitis Ono, Ayako Miura, Tomoyuki Araki, Shinji Yamaguchi, Kazunari Takatsuki, Kiyoshi Mori, Sigeo Hayami, Masanori Mochizuki, Manabu Watanabe, Toshiki Jpn J Cancer Res Rapid Communication The hypothesis that HTLV‐1 uveitis, a recently identified disease entity associated with human T‐cell leukemia virus type I (HTLV‐1), is caused by a specific subtype of the virus was tested. The nucleotide sequences of the long terminal repeat of HTLV‐1 from five patients with HTLV‐1 uveitis (HU) and four with adult T‐cell leukemia were phylogenetically analyzed. Our results showed that both subtypes which had been identified in Japan were associated with HU, indicating that there was no difference in pathogenicity between these phylogenetic subtypes. One of the subtypes was more frequently isolated in Okinawa than in Kyushu, suggesting a bias in the prevalence of each subtype among the inhabitants of these two areas of Japan. Blackwell Publishing Ltd 1994-08 /pmc/articles/PMC5919557/ /pubmed/7928620 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02945.x Text en |
spellingShingle | Rapid Communication Ono, Ayako Miura, Tomoyuki Araki, Shinji Yamaguchi, Kazunari Takatsuki, Kiyoshi Mori, Sigeo Hayami, Masanori Mochizuki, Manabu Watanabe, Toshiki Subtype Analysis of HTLV‐1 in Patients with HTLV‐1 Uveitis |
title | Subtype Analysis of HTLV‐1 in Patients with HTLV‐1 Uveitis |
title_full | Subtype Analysis of HTLV‐1 in Patients with HTLV‐1 Uveitis |
title_fullStr | Subtype Analysis of HTLV‐1 in Patients with HTLV‐1 Uveitis |
title_full_unstemmed | Subtype Analysis of HTLV‐1 in Patients with HTLV‐1 Uveitis |
title_short | Subtype Analysis of HTLV‐1 in Patients with HTLV‐1 Uveitis |
title_sort | subtype analysis of htlv‐1 in patients with htlv‐1 uveitis |
topic | Rapid Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919557/ https://www.ncbi.nlm.nih.gov/pubmed/7928620 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02945.x |
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