The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats

LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease reveal...

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Detalles Bibliográficos
Autores principales: Ono, Takao, Takada, Shigeyuki, Yoshida, Michihiro C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919571/
https://www.ncbi.nlm.nih.gov/pubmed/7928621
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02946.x
Descripción
Sumario:LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime candidate for the hts gene responsible for the hepatitis of LEG rats, and suggests that the hepatitis of LEC rats may be caused by a defect in a copper‐transporting ATPase expressed in the liver.

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