The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats

LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease reveal...

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Detalles Bibliográficos
Autores principales: Ono, Takao, Takada, Shigeyuki, Yoshida, Michihiro C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919571/
https://www.ncbi.nlm.nih.gov/pubmed/7928621
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02946.x
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author Ono, Takao
Takada, Shigeyuki
Yoshida, Michihiro C.
author_facet Ono, Takao
Takada, Shigeyuki
Yoshida, Michihiro C.
author_sort Ono, Takao
collection PubMed
description LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime candidate for the hts gene responsible for the hepatitis of LEG rats, and suggests that the hepatitis of LEC rats may be caused by a defect in a copper‐transporting ATPase expressed in the liver.
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spelling pubmed-59195712018-05-11 The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats Ono, Takao Takada, Shigeyuki Yoshida, Michihiro C. Jpn J Cancer Res Rapid Communication LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime candidate for the hts gene responsible for the hepatitis of LEG rats, and suggests that the hepatitis of LEC rats may be caused by a defect in a copper‐transporting ATPase expressed in the liver. Blackwell Publishing Ltd 1994-08 /pmc/articles/PMC5919571/ /pubmed/7928621 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02946.x Text en
spellingShingle Rapid Communication
Ono, Takao
Takada, Shigeyuki
Yoshida, Michihiro C.
The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats
title The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats
title_full The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats
title_fullStr The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats
title_full_unstemmed The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats
title_short The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats
title_sort wd gene for wilson's disease links to the hepatitis of leg rats
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919571/
https://www.ncbi.nlm.nih.gov/pubmed/7928621
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02946.x
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