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The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats
LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease reveal...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1994
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919571/ https://www.ncbi.nlm.nih.gov/pubmed/7928621 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02946.x |
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author | Ono, Takao Takada, Shigeyuki Yoshida, Michihiro C. |
author_facet | Ono, Takao Takada, Shigeyuki Yoshida, Michihiro C. |
author_sort | Ono, Takao |
collection | PubMed |
description | LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime candidate for the hts gene responsible for the hepatitis of LEG rats, and suggests that the hepatitis of LEC rats may be caused by a defect in a copper‐transporting ATPase expressed in the liver. |
format | Online Article Text |
id | pubmed-5919571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1994 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59195712018-05-11 The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats Ono, Takao Takada, Shigeyuki Yoshida, Michihiro C. Jpn J Cancer Res Rapid Communication LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime candidate for the hts gene responsible for the hepatitis of LEG rats, and suggests that the hepatitis of LEC rats may be caused by a defect in a copper‐transporting ATPase expressed in the liver. Blackwell Publishing Ltd 1994-08 /pmc/articles/PMC5919571/ /pubmed/7928621 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02946.x Text en |
spellingShingle | Rapid Communication Ono, Takao Takada, Shigeyuki Yoshida, Michihiro C. The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats |
title | The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats |
title_full | The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats |
title_fullStr | The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats |
title_full_unstemmed | The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats |
title_short | The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats |
title_sort | wd gene for wilson's disease links to the hepatitis of leg rats |
topic | Rapid Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919571/ https://www.ncbi.nlm.nih.gov/pubmed/7928621 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02946.x |
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