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Lack of Any Positive Effect of Intestinal Metaplasia on Induction of Gastric Tumors in Wistar Rats Treated with N‐Methyl‐N‐nitrosourea in Their Drinking Water

The influence of intestinal metaplasia on gastric cancer induction was examined in five‐week‐old male Wistan:Crj rats. The animals were first treated with two 10 Gy doses of X‐rays to the gastric region at a 3‐day interval (total 20 Gy) and then, starting two months after the irradiation, received 1...

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Detalles Bibliográficos
Autores principales: Watanabe, Hiromitsu, Ando, Yasumi, Yamada, Kazumasa, Okamoto, Taro, Ito, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919585/
https://www.ncbi.nlm.nih.gov/pubmed/7961116
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02965.x
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author Watanabe, Hiromitsu
Ando, Yasumi
Yamada, Kazumasa
Okamoto, Taro
Ito, Akihiro
author_facet Watanabe, Hiromitsu
Ando, Yasumi
Yamada, Kazumasa
Okamoto, Taro
Ito, Akihiro
author_sort Watanabe, Hiromitsu
collection PubMed
description The influence of intestinal metaplasia on gastric cancer induction was examined in five‐week‐old male Wistan:Crj rats. The animals were first treated with two 10 Gy doses of X‐rays to the gastric region at a 3‐day interval (total 20 Gy) and then, starting two months after the irradiation, received 100 ppm N‐methyl‐N‐nitrosourea (MNU) in their drinking water for 15 weeks. Thereafter they were maintained for 37 weeks with or without a dietary 1% sodium chloride (NaCl) supplement. The incidences of gastric adenocarcinomas in the MNU or MNU plus NaCl groups were significantly higher than in animals receiving X‐rays plus MNU with or without NaCl. Intestinal metaplasias and the numbers of alkaline phosphatase(ALP)‐positive foci were significantly increased in the X‐ray irradiation groups but the numbers of ALP‐positive foci were not increased with or without 1% NaCl. An inverse relationship between incidences of gastric tumors and intestinal metaplasias was apparent. The present experiment thus showed that the presence of intestinal metaplasia does not exert a positive influence on induction of gastric neoplasia by MNU in the rat.
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spelling pubmed-59195852018-05-11 Lack of Any Positive Effect of Intestinal Metaplasia on Induction of Gastric Tumors in Wistar Rats Treated with N‐Methyl‐N‐nitrosourea in Their Drinking Water Watanabe, Hiromitsu Ando, Yasumi Yamada, Kazumasa Okamoto, Taro Ito, Akihiro Jpn J Cancer Res Article The influence of intestinal metaplasia on gastric cancer induction was examined in five‐week‐old male Wistan:Crj rats. The animals were first treated with two 10 Gy doses of X‐rays to the gastric region at a 3‐day interval (total 20 Gy) and then, starting two months after the irradiation, received 100 ppm N‐methyl‐N‐nitrosourea (MNU) in their drinking water for 15 weeks. Thereafter they were maintained for 37 weeks with or without a dietary 1% sodium chloride (NaCl) supplement. The incidences of gastric adenocarcinomas in the MNU or MNU plus NaCl groups were significantly higher than in animals receiving X‐rays plus MNU with or without NaCl. Intestinal metaplasias and the numbers of alkaline phosphatase(ALP)‐positive foci were significantly increased in the X‐ray irradiation groups but the numbers of ALP‐positive foci were not increased with or without 1% NaCl. An inverse relationship between incidences of gastric tumors and intestinal metaplasias was apparent. The present experiment thus showed that the presence of intestinal metaplasia does not exert a positive influence on induction of gastric neoplasia by MNU in the rat. Blackwell Publishing Ltd 1994-09 /pmc/articles/PMC5919585/ /pubmed/7961116 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02965.x Text en
spellingShingle Article
Watanabe, Hiromitsu
Ando, Yasumi
Yamada, Kazumasa
Okamoto, Taro
Ito, Akihiro
Lack of Any Positive Effect of Intestinal Metaplasia on Induction of Gastric Tumors in Wistar Rats Treated with N‐Methyl‐N‐nitrosourea in Their Drinking Water
title Lack of Any Positive Effect of Intestinal Metaplasia on Induction of Gastric Tumors in Wistar Rats Treated with N‐Methyl‐N‐nitrosourea in Their Drinking Water
title_full Lack of Any Positive Effect of Intestinal Metaplasia on Induction of Gastric Tumors in Wistar Rats Treated with N‐Methyl‐N‐nitrosourea in Their Drinking Water
title_fullStr Lack of Any Positive Effect of Intestinal Metaplasia on Induction of Gastric Tumors in Wistar Rats Treated with N‐Methyl‐N‐nitrosourea in Their Drinking Water
title_full_unstemmed Lack of Any Positive Effect of Intestinal Metaplasia on Induction of Gastric Tumors in Wistar Rats Treated with N‐Methyl‐N‐nitrosourea in Their Drinking Water
title_short Lack of Any Positive Effect of Intestinal Metaplasia on Induction of Gastric Tumors in Wistar Rats Treated with N‐Methyl‐N‐nitrosourea in Their Drinking Water
title_sort lack of any positive effect of intestinal metaplasia on induction of gastric tumors in wistar rats treated with n‐methyl‐n‐nitrosourea in their drinking water
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919585/
https://www.ncbi.nlm.nih.gov/pubmed/7961116
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02965.x
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