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Targeted next generation sequencing identifies functionally deleterious germline mutations in novel genes in early-onset/familial prostate cancer

Considering that mutations in known prostate cancer (PrCa) predisposition genes, including those responsible for hereditary breast/ovarian cancer and Lynch syndromes, explain less than 5% of early-onset/familial PrCa, we have sequenced 94 genes associated with cancer predisposition using next genera...

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Detalles Bibliográficos
Autores principales:	Paulo, Paula, Maia, Sofia, Pinto, Carla, Pinto, Pedro, Monteiro, Augusta, Peixoto, Ana, Teixeira, Manuel R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919682/ https://www.ncbi.nlm.nih.gov/pubmed/29659569 http://dx.doi.org/10.1371/journal.pgen.1007355

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