Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions

The growth plate mediates bone growth where SOX9 and GLI factors control chondrocyte proliferation, differentiation and entry into hypertrophy. FOXA factors regulate hypertrophic chondrocyte maturation. How these factors integrate into a Gene Regulatory Network (GRN) controlling these differentiatio...

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Detalles Bibliográficos
Autores principales: Tan, Zhijia, Niu, Ben, Tsang, Kwok Yeung, Melhado, Ian G., Ohba, Shinsuke, He, Xinjun, Huang, Yongheng, Wang, Cheng, McMahon, Andrew P., Jauch, Ralf, Chan, Danny, Zhang, Michael Q., Cheah, Kathryn S. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919691/
https://www.ncbi.nlm.nih.gov/pubmed/29659575
http://dx.doi.org/10.1371/journal.pgen.1007346

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