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Allostery in the dengue virus NS3 helicase: Insights into the NTPase cycle from molecular simulations

The C-terminus domain of non-structural 3 (NS3) protein of the Flaviviridae viruses (e.g. HCV, dengue, West Nile, Zika) is a nucleotide triphosphatase (NTPase) -dependent superfamily 2 (SF2) helicase that unwinds double-stranded RNA while translocating along the nucleic polymer. Due to these functio...

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Detalles Bibliográficos
Autores principales:	Davidson, Russell B., Hendrix, Josie, Geiss, Brian J., McCullagh, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919694/ https://www.ncbi.nlm.nih.gov/pubmed/29659571 http://dx.doi.org/10.1371/journal.pcbi.1006103

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