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Dunce Phosphodiesterase Acts as a Checkpoint for Drosophila Long-Term Memory in a Pair of Serotonergic Neurons

A key function of the brain is to filter essential information and store it in the form of stable, long-term memory (LTM). We demonstrate here that the Dunce (Dnc) phosphodiesterase, an important enzyme that degrades cAMP, acts as a molecular switch that controls LTM formation in Drosophila. We show...

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Detalles Bibliográficos
Autores principales: Scheunemann, Lisa, Plaçais, Pierre-Yves, Dromard, Yann, Schwärzel, Martin, Preat, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919781/
https://www.ncbi.nlm.nih.gov/pubmed/29673482
http://dx.doi.org/10.1016/j.neuron.2018.03.032