Severe Adult-onset Still Disease with Constrictive Pericarditis and Pleuritis That Was Successfully Treated with Tocilizumab in Addition to Corticosteroids and Cyclosporin A

Adult-onset Still disease (AOSD) is a systemic inflammatory disease characterized by fever, arthritis and rash. Corticosteroids represent a promising therapeutic option for AOSD; however, some resistant cases require immunosuppressants and biologic agents. We herein report the case of a 29-year-old...

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Detalles Bibliográficos
Autores principales: Kawaguchi, Hoshimi, Tsuboi, Hiroto, Yagishita, Mizuki, Terasaki, Toshihiko, Terasaki, Mayu, Shimizu, Masaru, Honda, Fumika, Ohyama, Ayako, Takahashi, Hiroyuki, Miki, Haruka, Yokosawa, Masahiro, Asashima, Hiromitsu, Hagiwara, Shinya, Kondo, Yuya, Matsumoto, Isao, Sumida, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919867/
https://www.ncbi.nlm.nih.gov/pubmed/29269680
http://dx.doi.org/10.2169/internalmedicine.9809-17
Descripción
Sumario:Adult-onset Still disease (AOSD) is a systemic inflammatory disease characterized by fever, arthritis and rash. Corticosteroids represent a promising therapeutic option for AOSD; however, some resistant cases require immunosuppressants and biologic agents. We herein report the case of a 29-year-old Japanese man with severe AOSD, accompanied by constrictive pericarditis (CP) and pleuritis. Although 2 courses of steroid pulse and subsequent high-dose of prednisolone and cyclosporine A improved the patient's CP and pleuritis, his fever and inflammatory responses persisted. Tocilizumab (TCZ) was added to his treatment, which resulted in a rapid remission. This case suggests the usefulness of TCZ in the treatment of severe AOSD with CP and pleuritis.

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