Cargando…
Severe Adult-onset Still Disease with Constrictive Pericarditis and Pleuritis That Was Successfully Treated with Tocilizumab in Addition to Corticosteroids and Cyclosporin A
Adult-onset Still disease (AOSD) is a systemic inflammatory disease characterized by fever, arthritis and rash. Corticosteroids represent a promising therapeutic option for AOSD; however, some resistant cases require immunosuppressants and biologic agents. We herein report the case of a 29-year-old...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919867/ https://www.ncbi.nlm.nih.gov/pubmed/29269680 http://dx.doi.org/10.2169/internalmedicine.9809-17 |
_version_ | 1783317714773737472 |
---|---|
author | Kawaguchi, Hoshimi Tsuboi, Hiroto Yagishita, Mizuki Terasaki, Toshihiko Terasaki, Mayu Shimizu, Masaru Honda, Fumika Ohyama, Ayako Takahashi, Hiroyuki Miki, Haruka Yokosawa, Masahiro Asashima, Hiromitsu Hagiwara, Shinya Kondo, Yuya Matsumoto, Isao Sumida, Takayuki |
author_facet | Kawaguchi, Hoshimi Tsuboi, Hiroto Yagishita, Mizuki Terasaki, Toshihiko Terasaki, Mayu Shimizu, Masaru Honda, Fumika Ohyama, Ayako Takahashi, Hiroyuki Miki, Haruka Yokosawa, Masahiro Asashima, Hiromitsu Hagiwara, Shinya Kondo, Yuya Matsumoto, Isao Sumida, Takayuki |
author_sort | Kawaguchi, Hoshimi |
collection | PubMed |
description | Adult-onset Still disease (AOSD) is a systemic inflammatory disease characterized by fever, arthritis and rash. Corticosteroids represent a promising therapeutic option for AOSD; however, some resistant cases require immunosuppressants and biologic agents. We herein report the case of a 29-year-old Japanese man with severe AOSD, accompanied by constrictive pericarditis (CP) and pleuritis. Although 2 courses of steroid pulse and subsequent high-dose of prednisolone and cyclosporine A improved the patient's CP and pleuritis, his fever and inflammatory responses persisted. Tocilizumab (TCZ) was added to his treatment, which resulted in a rapid remission. This case suggests the usefulness of TCZ in the treatment of severe AOSD with CP and pleuritis. |
format | Online Article Text |
id | pubmed-5919867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-59198672018-04-27 Severe Adult-onset Still Disease with Constrictive Pericarditis and Pleuritis That Was Successfully Treated with Tocilizumab in Addition to Corticosteroids and Cyclosporin A Kawaguchi, Hoshimi Tsuboi, Hiroto Yagishita, Mizuki Terasaki, Toshihiko Terasaki, Mayu Shimizu, Masaru Honda, Fumika Ohyama, Ayako Takahashi, Hiroyuki Miki, Haruka Yokosawa, Masahiro Asashima, Hiromitsu Hagiwara, Shinya Kondo, Yuya Matsumoto, Isao Sumida, Takayuki Intern Med Case Report Adult-onset Still disease (AOSD) is a systemic inflammatory disease characterized by fever, arthritis and rash. Corticosteroids represent a promising therapeutic option for AOSD; however, some resistant cases require immunosuppressants and biologic agents. We herein report the case of a 29-year-old Japanese man with severe AOSD, accompanied by constrictive pericarditis (CP) and pleuritis. Although 2 courses of steroid pulse and subsequent high-dose of prednisolone and cyclosporine A improved the patient's CP and pleuritis, his fever and inflammatory responses persisted. Tocilizumab (TCZ) was added to his treatment, which resulted in a rapid remission. This case suggests the usefulness of TCZ in the treatment of severe AOSD with CP and pleuritis. The Japanese Society of Internal Medicine 2017-12-21 2018-04-01 /pmc/articles/PMC5919867/ /pubmed/29269680 http://dx.doi.org/10.2169/internalmedicine.9809-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Kawaguchi, Hoshimi Tsuboi, Hiroto Yagishita, Mizuki Terasaki, Toshihiko Terasaki, Mayu Shimizu, Masaru Honda, Fumika Ohyama, Ayako Takahashi, Hiroyuki Miki, Haruka Yokosawa, Masahiro Asashima, Hiromitsu Hagiwara, Shinya Kondo, Yuya Matsumoto, Isao Sumida, Takayuki Severe Adult-onset Still Disease with Constrictive Pericarditis and Pleuritis That Was Successfully Treated with Tocilizumab in Addition to Corticosteroids and Cyclosporin A |
title | Severe Adult-onset Still Disease with Constrictive Pericarditis and Pleuritis That Was Successfully Treated with Tocilizumab in Addition to Corticosteroids and Cyclosporin A |
title_full | Severe Adult-onset Still Disease with Constrictive Pericarditis and Pleuritis That Was Successfully Treated with Tocilizumab in Addition to Corticosteroids and Cyclosporin A |
title_fullStr | Severe Adult-onset Still Disease with Constrictive Pericarditis and Pleuritis That Was Successfully Treated with Tocilizumab in Addition to Corticosteroids and Cyclosporin A |
title_full_unstemmed | Severe Adult-onset Still Disease with Constrictive Pericarditis and Pleuritis That Was Successfully Treated with Tocilizumab in Addition to Corticosteroids and Cyclosporin A |
title_short | Severe Adult-onset Still Disease with Constrictive Pericarditis and Pleuritis That Was Successfully Treated with Tocilizumab in Addition to Corticosteroids and Cyclosporin A |
title_sort | severe adult-onset still disease with constrictive pericarditis and pleuritis that was successfully treated with tocilizumab in addition to corticosteroids and cyclosporin a |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919867/ https://www.ncbi.nlm.nih.gov/pubmed/29269680 http://dx.doi.org/10.2169/internalmedicine.9809-17 |
work_keys_str_mv | AT kawaguchihoshimi severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT tsuboihiroto severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT yagishitamizuki severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT terasakitoshihiko severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT terasakimayu severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT shimizumasaru severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT hondafumika severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT ohyamaayako severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT takahashihiroyuki severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT mikiharuka severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT yokosawamasahiro severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT asashimahiromitsu severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT hagiwarashinya severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT kondoyuya severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT matsumotoisao severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina AT sumidatakayuki severeadultonsetstilldiseasewithconstrictivepericarditisandpleuritisthatwassuccessfullytreatedwithtocilizumabinadditiontocorticosteroidsandcyclosporina |