PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect

PGC1α acts as a central regulator of mitochondrial metabolism, whose role in cancer progression has been highlighted but remains largely undefined. Especially, it is completely unknown about the effect of PGC1α on cholangiocarcinoma (CCA). Here we showed that PGC1α overexpression had no impact on CC...

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Detalles Bibliográficos
Autores principales: Dan Li, Wang, Chaoqun, Ma, Panfei, Yu, Qingan, Gu, Mingqi, Dong, Liqian, Jiang, Wenjing, Pan, Shangha, Xie, Changming, Han, Jihua, Lan, Yaliang, Sun, Jing, Sheng, Ping, Liu, Kunpeng, Wu, Yaohua, Liu, Lianxin, Ma, Yong, Jiang, Hongchi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919932/
https://www.ncbi.nlm.nih.gov/pubmed/29700317
http://dx.doi.org/10.1038/s41419-018-0494-0

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