Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Influences Sensitivity to Anti-IGF System Agents Through the Translational Regulation of IGF1R

Insulin-like growth factor 2 (IGF2) mRNA-binding protein 3 (IGF2BP3) is an oncofetal protein that binds RNA, thereby influencing the fate of target transcripts. IGF2BP3 is synthesized de novo in cancer, where it promotes proliferation, drug resistance, and metastasis via both IGF2-dependent and IGF2...

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Autores principales: Mancarella, Caterina, Pasello, Michela, Manara, Maria Cristina, Toracchio, Lisa, Sciandra, Evelina Fiorenza, Picci, Piero, Scotlandi, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919949/
https://www.ncbi.nlm.nih.gov/pubmed/29731738
http://dx.doi.org/10.3389/fendo.2018.00178

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