NOTCH1 Is Aberrantly Activated in Chronic Lymphocytic Leukemia Hematopoietic Stem Cells

To investigate chronic lymphocytic leukemia (CLL)-initiating cells, we assessed NOTCH1 mutation/expression in hematopoietic stem cells (HSCs). In NOTCH1-mutated CLL, we detected subclonal mutations in 57% CD34+/CD38− HSCs. NOTCH1 mutation was present in 66% CD34+/CD38+ progenitor cells displaying an...

Descripción completa

Detalles Bibliográficos
Autores principales: Di Ianni, Mauro, Baldoni, Stefano, Del Papa, Beatrice, Aureli, Patrizia, Dorillo, Erica, De Falco, Filomena, Albi, Elisa, Varasano, Emanuela, Di Tommaso, Ambra, Giancola, Raffaella, Accorsi, Patrizia, Rotta, Gianluca, Rompietti, Chiara, Silva Barcelos, Estevão Carlos, Campese, Antonio Francesco, Di Bartolomeo, Paolo, Screpanti, Isabella, Rosati, Emanuela, Falzetti, Franca, Sportoletti, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919960/
https://www.ncbi.nlm.nih.gov/pubmed/29732315
http://dx.doi.org/10.3389/fonc.2018.00105

Ejemplares similares

Ejemplares similares