Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors

Altered mitochondrial dynamics can broadly impact tumor cell physiology. Using genetic and pharmacological profiling of cancer cell lines and human tumors, we here establish that perturbations to the mitochondrial dynamics network also result in specific therapeutic vulnerabilities. In particular, t...

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Detalles Bibliográficos
Autores principales: Anderson, Gray R., Wardell, Suzanne E., Cakir, Merve, Yip, Catherine, Ahn, Yeong-ran, Ali, Moiez, Yllanes, Alexander P., Chao, Christina A., McDonnell, Donald P., Wood, Kris C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919970/
https://www.ncbi.nlm.nih.gov/pubmed/29700304
http://dx.doi.org/10.1038/s41467-018-04033-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919970/
https://www.ncbi.nlm.nih.gov/pubmed/29700304
http://dx.doi.org/10.1038/s41467-018-04033-x

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