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Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis
Host’s physiology is significantly influenced by microbiota colonizing the epithelial surfaces. Complex microbial communities contribute to proper mucosal barrier function, immune response, and prevention of pathogen invasion and have many other crucial functions. The oral cavity and large intestine...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920026/ https://www.ncbi.nlm.nih.gov/pubmed/29731748 http://dx.doi.org/10.3389/fmicb.2018.00774 |
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author | Klimesova, Klara Jiraskova Zakostelska, Zuzana Tlaskalova-Hogenova, Helena |
author_facet | Klimesova, Klara Jiraskova Zakostelska, Zuzana Tlaskalova-Hogenova, Helena |
author_sort | Klimesova, Klara |
collection | PubMed |
description | Host’s physiology is significantly influenced by microbiota colonizing the epithelial surfaces. Complex microbial communities contribute to proper mucosal barrier function, immune response, and prevention of pathogen invasion and have many other crucial functions. The oral cavity and large intestine are distant parts of the digestive tract, both heavily colonized by commensal microbiota. Nevertheless, they feature different proportions of major bacterial and fungal phyla, mostly due to distinct epithelial layers organization and different oxygen levels. A few obligate anaerobic strains inhabiting the oral cavity are involved in the pathogenesis of oral diseases. Interestingly, these microbiota components are also enriched in gut inflammatory and tumor tissue. An altered microbiota composition – dysbiosis – and formation of polymicrobial biofilms seem to play important roles in the development of oral diseases and colorectal cancer. In this review, we describe the differences in composition of commensal microbiota in the oral cavity and large intestine and the mechanisms by which microbiota affect the inflammatory and carcinogenic response of the host. |
format | Online Article Text |
id | pubmed-5920026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59200262018-05-04 Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis Klimesova, Klara Jiraskova Zakostelska, Zuzana Tlaskalova-Hogenova, Helena Front Microbiol Microbiology Host’s physiology is significantly influenced by microbiota colonizing the epithelial surfaces. Complex microbial communities contribute to proper mucosal barrier function, immune response, and prevention of pathogen invasion and have many other crucial functions. The oral cavity and large intestine are distant parts of the digestive tract, both heavily colonized by commensal microbiota. Nevertheless, they feature different proportions of major bacterial and fungal phyla, mostly due to distinct epithelial layers organization and different oxygen levels. A few obligate anaerobic strains inhabiting the oral cavity are involved in the pathogenesis of oral diseases. Interestingly, these microbiota components are also enriched in gut inflammatory and tumor tissue. An altered microbiota composition – dysbiosis – and formation of polymicrobial biofilms seem to play important roles in the development of oral diseases and colorectal cancer. In this review, we describe the differences in composition of commensal microbiota in the oral cavity and large intestine and the mechanisms by which microbiota affect the inflammatory and carcinogenic response of the host. Frontiers Media S.A. 2018-04-20 /pmc/articles/PMC5920026/ /pubmed/29731748 http://dx.doi.org/10.3389/fmicb.2018.00774 Text en Copyright © 2018 Klimesova, Jiraskova Zakostelska and Tlaskalova-Hogenova. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Klimesova, Klara Jiraskova Zakostelska, Zuzana Tlaskalova-Hogenova, Helena Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis |
title | Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis |
title_full | Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis |
title_fullStr | Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis |
title_full_unstemmed | Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis |
title_short | Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis |
title_sort | oral bacterial and fungal microbiome impacts colorectal carcinogenesis |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920026/ https://www.ncbi.nlm.nih.gov/pubmed/29731748 http://dx.doi.org/10.3389/fmicb.2018.00774 |
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