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Tilted grating phase-contrast computed tomography using statistical iterative reconstruction
Grating-based phase-contrast computed tomography (GBPC-CT) enables increased soft tissue differentiation, but often suffers from streak artifacts when performing high-sensitivity GBPC-CT of biomedical samples. Current GBPC-CT setups consist of one-dimensional gratings and hence allow to measure only...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920057/ https://www.ncbi.nlm.nih.gov/pubmed/29700372 http://dx.doi.org/10.1038/s41598-018-25075-7 |
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author | Birnbacher, Lorenz Viermetz, Manuel Noichl, Wolfgang Allner, Sebastian Fehringer, Andreas Marschner, Mathias von Teuffenbach, Maximilian Willner, Marian Achterhold, Klaus Noël, Peter B. Koehler, Thomas Herzen, Julia Pfeiffer, Franz |
author_facet | Birnbacher, Lorenz Viermetz, Manuel Noichl, Wolfgang Allner, Sebastian Fehringer, Andreas Marschner, Mathias von Teuffenbach, Maximilian Willner, Marian Achterhold, Klaus Noël, Peter B. Koehler, Thomas Herzen, Julia Pfeiffer, Franz |
author_sort | Birnbacher, Lorenz |
collection | PubMed |
description | Grating-based phase-contrast computed tomography (GBPC-CT) enables increased soft tissue differentiation, but often suffers from streak artifacts when performing high-sensitivity GBPC-CT of biomedical samples. Current GBPC-CT setups consist of one-dimensional gratings and hence allow to measure only the differential phase-contrast (DPC) signal perpendicular to the direction of the grating lines. Having access to the full two-dimensional DPC signal can strongly reduce streak artefacts showing up as characteristic horizontal lines in the reconstructed images. GBPC-CT with gratings tilted by 45° around the optical axis, combining opposed projections, and reconstructing with filtered backprojection is one method to retrieve the full three-dimensional DPC signal. This approach improves the quality of the tomographic data as already demonstrated at a synchrotron facility. However, additional processing and interpolation is necessary, and the approach fails when dealing with cone-beam geometry setups. In this work, we employ the tilted grating configuration with a laboratory GBPC-CT setup with cone-beam geometry and use statistical iterative reconstruction (SIR) with a forward model accounting for diagonal grating alignment. Our results show a strong reduction of streak artefacts and significant increase in image quality. In contrast to the prior approach our proposed method can be used in a laboratory environment due to its cone-beam compatibility. |
format | Online Article Text |
id | pubmed-5920057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59200572018-05-01 Tilted grating phase-contrast computed tomography using statistical iterative reconstruction Birnbacher, Lorenz Viermetz, Manuel Noichl, Wolfgang Allner, Sebastian Fehringer, Andreas Marschner, Mathias von Teuffenbach, Maximilian Willner, Marian Achterhold, Klaus Noël, Peter B. Koehler, Thomas Herzen, Julia Pfeiffer, Franz Sci Rep Article Grating-based phase-contrast computed tomography (GBPC-CT) enables increased soft tissue differentiation, but often suffers from streak artifacts when performing high-sensitivity GBPC-CT of biomedical samples. Current GBPC-CT setups consist of one-dimensional gratings and hence allow to measure only the differential phase-contrast (DPC) signal perpendicular to the direction of the grating lines. Having access to the full two-dimensional DPC signal can strongly reduce streak artefacts showing up as characteristic horizontal lines in the reconstructed images. GBPC-CT with gratings tilted by 45° around the optical axis, combining opposed projections, and reconstructing with filtered backprojection is one method to retrieve the full three-dimensional DPC signal. This approach improves the quality of the tomographic data as already demonstrated at a synchrotron facility. However, additional processing and interpolation is necessary, and the approach fails when dealing with cone-beam geometry setups. In this work, we employ the tilted grating configuration with a laboratory GBPC-CT setup with cone-beam geometry and use statistical iterative reconstruction (SIR) with a forward model accounting for diagonal grating alignment. Our results show a strong reduction of streak artefacts and significant increase in image quality. In contrast to the prior approach our proposed method can be used in a laboratory environment due to its cone-beam compatibility. Nature Publishing Group UK 2018-04-26 /pmc/articles/PMC5920057/ /pubmed/29700372 http://dx.doi.org/10.1038/s41598-018-25075-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Birnbacher, Lorenz Viermetz, Manuel Noichl, Wolfgang Allner, Sebastian Fehringer, Andreas Marschner, Mathias von Teuffenbach, Maximilian Willner, Marian Achterhold, Klaus Noël, Peter B. Koehler, Thomas Herzen, Julia Pfeiffer, Franz Tilted grating phase-contrast computed tomography using statistical iterative reconstruction |
title | Tilted grating phase-contrast computed tomography using statistical iterative reconstruction |
title_full | Tilted grating phase-contrast computed tomography using statistical iterative reconstruction |
title_fullStr | Tilted grating phase-contrast computed tomography using statistical iterative reconstruction |
title_full_unstemmed | Tilted grating phase-contrast computed tomography using statistical iterative reconstruction |
title_short | Tilted grating phase-contrast computed tomography using statistical iterative reconstruction |
title_sort | tilted grating phase-contrast computed tomography using statistical iterative reconstruction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920057/ https://www.ncbi.nlm.nih.gov/pubmed/29700372 http://dx.doi.org/10.1038/s41598-018-25075-7 |
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