Skin infection boosts memory B-cells specific for a cryptic vaccine epitope of group A streptococcus and broadens the immune response to enhance vaccine efficacy

Antigenic diversity of the M protein is a major constraint to the development of immunity to group A streptococcus (GAS). We demonstrate that a conserved cryptic epitope that is unrecognized by the host immune system following infection can protect mice following vaccination, and that immunity is st...

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Autores principales: Pandey, Manisha, Ozberk, Victoria, Langshaw, Emma L., Calcutt, Ainslie, Powell, Jessica, Batzloff, Michael R., Rivera-Hernandez, Tania, Good, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920117/
https://www.ncbi.nlm.nih.gov/pubmed/29736269
http://dx.doi.org/10.1038/s41541-018-0053-9
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author Pandey, Manisha
Ozberk, Victoria
Langshaw, Emma L.
Calcutt, Ainslie
Powell, Jessica
Batzloff, Michael R.
Rivera-Hernandez, Tania
Good, Michael F.
author_facet Pandey, Manisha
Ozberk, Victoria
Langshaw, Emma L.
Calcutt, Ainslie
Powell, Jessica
Batzloff, Michael R.
Rivera-Hernandez, Tania
Good, Michael F.
author_sort Pandey, Manisha
collection PubMed
description Antigenic diversity of the M protein is a major constraint to the development of immunity to group A streptococcus (GAS). We demonstrate that a conserved cryptic epitope that is unrecognized by the host immune system following infection can protect mice following vaccination, and that immunity is strengthened and broadened following successive infections. The observation that infection can boost and broaden, but cannot prime immunity to a cryptic epitope, may be exploited for vaccines for other pathogens.
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spelling pubmed-59201172018-05-07 Skin infection boosts memory B-cells specific for a cryptic vaccine epitope of group A streptococcus and broadens the immune response to enhance vaccine efficacy Pandey, Manisha Ozberk, Victoria Langshaw, Emma L. Calcutt, Ainslie Powell, Jessica Batzloff, Michael R. Rivera-Hernandez, Tania Good, Michael F. NPJ Vaccines Brief Communication Antigenic diversity of the M protein is a major constraint to the development of immunity to group A streptococcus (GAS). We demonstrate that a conserved cryptic epitope that is unrecognized by the host immune system following infection can protect mice following vaccination, and that immunity is strengthened and broadened following successive infections. The observation that infection can boost and broaden, but cannot prime immunity to a cryptic epitope, may be exploited for vaccines for other pathogens. Nature Publishing Group UK 2018-04-26 /pmc/articles/PMC5920117/ /pubmed/29736269 http://dx.doi.org/10.1038/s41541-018-0053-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Pandey, Manisha
Ozberk, Victoria
Langshaw, Emma L.
Calcutt, Ainslie
Powell, Jessica
Batzloff, Michael R.
Rivera-Hernandez, Tania
Good, Michael F.
Skin infection boosts memory B-cells specific for a cryptic vaccine epitope of group A streptococcus and broadens the immune response to enhance vaccine efficacy
title Skin infection boosts memory B-cells specific for a cryptic vaccine epitope of group A streptococcus and broadens the immune response to enhance vaccine efficacy
title_full Skin infection boosts memory B-cells specific for a cryptic vaccine epitope of group A streptococcus and broadens the immune response to enhance vaccine efficacy
title_fullStr Skin infection boosts memory B-cells specific for a cryptic vaccine epitope of group A streptococcus and broadens the immune response to enhance vaccine efficacy
title_full_unstemmed Skin infection boosts memory B-cells specific for a cryptic vaccine epitope of group A streptococcus and broadens the immune response to enhance vaccine efficacy
title_short Skin infection boosts memory B-cells specific for a cryptic vaccine epitope of group A streptococcus and broadens the immune response to enhance vaccine efficacy
title_sort skin infection boosts memory b-cells specific for a cryptic vaccine epitope of group a streptococcus and broadens the immune response to enhance vaccine efficacy
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920117/
https://www.ncbi.nlm.nih.gov/pubmed/29736269
http://dx.doi.org/10.1038/s41541-018-0053-9
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