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Complex regression Doppler optical coherence tomography

We introduce a new method to measure Doppler shifts more accurately and extend the dynamic range of Doppler optical coherence tomography (OCT). The two-point estimate of the conventional Doppler method is replaced with a regression that is applied to high-density B-scans in polar coordinates. We bui...

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Autores principales: Elahi, Sahar, Gu, Shi, Thrane, Lars, Rollins, Andrew M., Jenkins, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920204/
https://www.ncbi.nlm.nih.gov/pubmed/29704328
http://dx.doi.org/10.1117/1.JBO.23.4.046009
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author Elahi, Sahar
Gu, Shi
Thrane, Lars
Rollins, Andrew M.
Jenkins, Michael W.
author_facet Elahi, Sahar
Gu, Shi
Thrane, Lars
Rollins, Andrew M.
Jenkins, Michael W.
author_sort Elahi, Sahar
collection PubMed
description We introduce a new method to measure Doppler shifts more accurately and extend the dynamic range of Doppler optical coherence tomography (OCT). The two-point estimate of the conventional Doppler method is replaced with a regression that is applied to high-density B-scans in polar coordinates. We built a high-speed OCT system using a 1.68-MHz Fourier domain mode locked laser to acquire high-density B-scans (16,000 A-lines) at high enough frame rates ([Formula: see text]) to accurately capture the dynamics of the beating embryonic heart. Flow phantom experiments confirm that the complex regression lowers the minimum detectable velocity from [Formula: see text] to [Formula: see text] , whereas the maximum velocity of [Formula: see text] is measured without phase wrapping. Complex regression Doppler OCT also demonstrates higher accuracy and precision compared with the conventional method, particularly when signal-to-noise ratio is low. The extended dynamic range allows monitoring of blood flow over several stages of development in embryos without adjusting the imaging parameters. In addition, applying complex averaging recovers hidden features in structural images.
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spelling pubmed-59202042019-04-27 Complex regression Doppler optical coherence tomography Elahi, Sahar Gu, Shi Thrane, Lars Rollins, Andrew M. Jenkins, Michael W. J Biomed Opt Research Papers: Imaging We introduce a new method to measure Doppler shifts more accurately and extend the dynamic range of Doppler optical coherence tomography (OCT). The two-point estimate of the conventional Doppler method is replaced with a regression that is applied to high-density B-scans in polar coordinates. We built a high-speed OCT system using a 1.68-MHz Fourier domain mode locked laser to acquire high-density B-scans (16,000 A-lines) at high enough frame rates ([Formula: see text]) to accurately capture the dynamics of the beating embryonic heart. Flow phantom experiments confirm that the complex regression lowers the minimum detectable velocity from [Formula: see text] to [Formula: see text] , whereas the maximum velocity of [Formula: see text] is measured without phase wrapping. Complex regression Doppler OCT also demonstrates higher accuracy and precision compared with the conventional method, particularly when signal-to-noise ratio is low. The extended dynamic range allows monitoring of blood flow over several stages of development in embryos without adjusting the imaging parameters. In addition, applying complex averaging recovers hidden features in structural images. Society of Photo-Optical Instrumentation Engineers 2018-04-27 2018-04 /pmc/articles/PMC5920204/ /pubmed/29704328 http://dx.doi.org/10.1117/1.JBO.23.4.046009 Text en © The Authors. https://creativecommons.org/licenses/by/3.0/ Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle Research Papers: Imaging
Elahi, Sahar
Gu, Shi
Thrane, Lars
Rollins, Andrew M.
Jenkins, Michael W.
Complex regression Doppler optical coherence tomography
title Complex regression Doppler optical coherence tomography
title_full Complex regression Doppler optical coherence tomography
title_fullStr Complex regression Doppler optical coherence tomography
title_full_unstemmed Complex regression Doppler optical coherence tomography
title_short Complex regression Doppler optical coherence tomography
title_sort complex regression doppler optical coherence tomography
topic Research Papers: Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920204/
https://www.ncbi.nlm.nih.gov/pubmed/29704328
http://dx.doi.org/10.1117/1.JBO.23.4.046009
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