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Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report
Long-term cetuximab treatment can lead to acquired resistance, and tumor progression and/or new lesions often occur. The present report describes a case of lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment in a 60-year-old man, including findings of an...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920247/ https://www.ncbi.nlm.nih.gov/pubmed/29725438 http://dx.doi.org/10.3892/ol.2018.8261 |
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author | Naruse, Tomofumi Tokuhisa, Mitsuko Yanamoto, Souichi Sakamoto, Yuki Okuyama, Kohei Tsuchihashi, Hiroki Umeda, Masahiro |
author_facet | Naruse, Tomofumi Tokuhisa, Mitsuko Yanamoto, Souichi Sakamoto, Yuki Okuyama, Kohei Tsuchihashi, Hiroki Umeda, Masahiro |
author_sort | Naruse, Tomofumi |
collection | PubMed |
description | Long-term cetuximab treatment can lead to acquired resistance, and tumor progression and/or new lesions often occur. The present report describes a case of lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment in a 60-year-old man, including findings of an immunohistochemical study. The resected primary tumors, biopsy of the lung metastasis before administration of cetuximab, and brain metastasis specimens mediated by cetuximab were immunohistochemically examined. Histologically, the metastatic brain lesion showed hyperkeratinizing tumor cells with deeply stained irregular nuclei with necrotizing tumor cells, and a decrease in cell density was exhibited in part of the tumor nest. Moreover, the brain lesion was less malignant compared with the primary tumor and metastatic lung lesions. Immunohistochemically, the metastatic brain lesions showed low expression of epidermal growth factor receptor (EGFR) and high expression of N-cadherin compared with the primary tumor and metastatic lung lesions. These results suggest that acquired resistance to cetuximab may be associated with low EGFR expression and increased epithelial-to-mesenchymal transition potential. |
format | Online Article Text |
id | pubmed-5920247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-59202472018-05-03 Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report Naruse, Tomofumi Tokuhisa, Mitsuko Yanamoto, Souichi Sakamoto, Yuki Okuyama, Kohei Tsuchihashi, Hiroki Umeda, Masahiro Oncol Lett Articles Long-term cetuximab treatment can lead to acquired resistance, and tumor progression and/or new lesions often occur. The present report describes a case of lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment in a 60-year-old man, including findings of an immunohistochemical study. The resected primary tumors, biopsy of the lung metastasis before administration of cetuximab, and brain metastasis specimens mediated by cetuximab were immunohistochemically examined. Histologically, the metastatic brain lesion showed hyperkeratinizing tumor cells with deeply stained irregular nuclei with necrotizing tumor cells, and a decrease in cell density was exhibited in part of the tumor nest. Moreover, the brain lesion was less malignant compared with the primary tumor and metastatic lung lesions. Immunohistochemically, the metastatic brain lesions showed low expression of epidermal growth factor receptor (EGFR) and high expression of N-cadherin compared with the primary tumor and metastatic lung lesions. These results suggest that acquired resistance to cetuximab may be associated with low EGFR expression and increased epithelial-to-mesenchymal transition potential. D.A. Spandidos 2018-05 2018-03-14 /pmc/articles/PMC5920247/ /pubmed/29725438 http://dx.doi.org/10.3892/ol.2018.8261 Text en Copyright: © Naruse et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Naruse, Tomofumi Tokuhisa, Mitsuko Yanamoto, Souichi Sakamoto, Yuki Okuyama, Kohei Tsuchihashi, Hiroki Umeda, Masahiro Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report |
title | Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report |
title_full | Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report |
title_fullStr | Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report |
title_full_unstemmed | Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report |
title_short | Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report |
title_sort | lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: a case report |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920247/ https://www.ncbi.nlm.nih.gov/pubmed/29725438 http://dx.doi.org/10.3892/ol.2018.8261 |
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