Mutant monocyte chemoattractant protein-1 protein (7ND) inhibits osteoclast differentiation and reduces oral squamous carcinoma cell bone invasion

The seven-amino acid truncated (7ND) protein is an N-terminal deletion mutant of monocyte chemoattractant protein-1 (MCP-1) and it functions as a dominant-negative inhibitor. 7ND and wild-type MCP-1 form a heterodimer, which binds to MCP-1 receptors and inhibits monocyte chemotaxis. In the present s...

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Detalles Bibliográficos
Autores principales: Luo, Shuyu, Zhou, Chuanxiang, Zhang, Jianming, Chen, Mengshan, Li, Hongjie, Zheng, Shanchuan, Quan, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920317/
https://www.ncbi.nlm.nih.gov/pubmed/29725470
http://dx.doi.org/10.3892/ol.2018.8308

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