Combined use of urinary Survivin detection and liquid-based cytology for the early diagnosis of bladder urothelial carcinoma

To assess the possibility of combined using urine Survivin and liquid-based cytology (LBC) tests to improve the diagnosis of bladder urothelial carcinoma (BUC), the present study analyzed urine from 36 patients with bladder cancer and 36 benign cases as control individuals. The Survivin content in the patient's morning urine was assessed by ELISA. When the sample value exceeded double of the average of the control group, it was defined as positive and the patient was diagnosed as bladder cancer. Meanwhile, LBC was performed for the same sample. Urinary Survivin detection combined with LBC test showed a sensitivity of 91.7%, a specificity of 91.7% and accuracy of 91.7% for the diagnosis of BUC. Compared with each test individually, although the specificity decreased, the sensitivity and accuracy of the combined detection improved significantly (P<0.05). The data presented in the current study identified that the LBC test is a novel diagnostic method for urinary tract tumors and its detection rate was superior to the conventional urine cytology test. Additionally, Survivin detection combined with LBC could significantly improve the detection rate of BUC. In addition, this method is non-invasive, economical, simple and precise.