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CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis

Breast cancer (BC) is the most commonly diagnosed cancer in females globally and is more aggressive at later stages. Chromosome region maintenance 1 (CRM1) is involved in the nuclear export of proteins and RNAs and has been associated with a number of malignancies. However, the clinicopathological s...

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Autores principales: Yue, Lu, Sun, Zhen-Ni, Yao, Ya-Sai, Shen, Zan, Wang, Hai-Bo, Liu, Xiang-Ping, Zhou, Fang, Xiang, Jin-Yu, Yao, Ru-Yong, Niu, Hai-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920404/
https://www.ncbi.nlm.nih.gov/pubmed/29725458
http://dx.doi.org/10.3892/ol.2018.8316
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author Yue, Lu
Sun, Zhen-Ni
Yao, Ya-Sai
Shen, Zan
Wang, Hai-Bo
Liu, Xiang-Ping
Zhou, Fang
Xiang, Jin-Yu
Yao, Ru-Yong
Niu, Hai-Tao
author_facet Yue, Lu
Sun, Zhen-Ni
Yao, Ya-Sai
Shen, Zan
Wang, Hai-Bo
Liu, Xiang-Ping
Zhou, Fang
Xiang, Jin-Yu
Yao, Ru-Yong
Niu, Hai-Tao
author_sort Yue, Lu
collection PubMed
description Breast cancer (BC) is the most commonly diagnosed cancer in females globally and is more aggressive at later stages. Chromosome region maintenance 1 (CRM1) is involved in the nuclear export of proteins and RNAs and has been associated with a number of malignancies. However, the clinicopathological significance of its expression in BC remains to be elucidated therefore this was investigated in the present study. CRM1 expression in 280 breast cancer tissues and 60 normal tissues was retrospectively analyzed using immunohistochemistry (IHC) and western blotting. IHC investigation demonstrated that CRM1 expression was significantly increased in BC compared with the normal breast epithelium (P<0.0001). Overexpression of CRM1 was markedly associated with poor prognostic characteristics, including larger tumor size (P=0.024), positive lymph node metastasis (P=0.032), invasive histological type (P=0.004) and distant metastasis (P=0.026). Significant associations were also observed between increased CRM1 expression and the progesterone receptor (P=0.028) and Ki67 (P=0.019). Kaplan-Meier survival analysis demonstrated that patients with high CRM1 expression exhibited a reduced disease-free survival and overall survival compared with those with low CRM1 expression (P=0.013). In the multivariate analysis, CRM1 expression (P=0.011), tumor size (P=0.001) and lymph node metastasis (P<0.001) were independent prognostic markers of BC. In conclusion, CRM1 serves an important role in BC and may serve as a predictive and prognostic factor for a poor outcome in patients with BC.
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spelling pubmed-59204042018-05-03 CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis Yue, Lu Sun, Zhen-Ni Yao, Ya-Sai Shen, Zan Wang, Hai-Bo Liu, Xiang-Ping Zhou, Fang Xiang, Jin-Yu Yao, Ru-Yong Niu, Hai-Tao Oncol Lett Articles Breast cancer (BC) is the most commonly diagnosed cancer in females globally and is more aggressive at later stages. Chromosome region maintenance 1 (CRM1) is involved in the nuclear export of proteins and RNAs and has been associated with a number of malignancies. However, the clinicopathological significance of its expression in BC remains to be elucidated therefore this was investigated in the present study. CRM1 expression in 280 breast cancer tissues and 60 normal tissues was retrospectively analyzed using immunohistochemistry (IHC) and western blotting. IHC investigation demonstrated that CRM1 expression was significantly increased in BC compared with the normal breast epithelium (P<0.0001). Overexpression of CRM1 was markedly associated with poor prognostic characteristics, including larger tumor size (P=0.024), positive lymph node metastasis (P=0.032), invasive histological type (P=0.004) and distant metastasis (P=0.026). Significant associations were also observed between increased CRM1 expression and the progesterone receptor (P=0.028) and Ki67 (P=0.019). Kaplan-Meier survival analysis demonstrated that patients with high CRM1 expression exhibited a reduced disease-free survival and overall survival compared with those with low CRM1 expression (P=0.013). In the multivariate analysis, CRM1 expression (P=0.011), tumor size (P=0.001) and lymph node metastasis (P<0.001) were independent prognostic markers of BC. In conclusion, CRM1 serves an important role in BC and may serve as a predictive and prognostic factor for a poor outcome in patients with BC. D.A. Spandidos 2018-05 2018-03-22 /pmc/articles/PMC5920404/ /pubmed/29725458 http://dx.doi.org/10.3892/ol.2018.8316 Text en Copyright: © Yue et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Yue, Lu
Sun, Zhen-Ni
Yao, Ya-Sai
Shen, Zan
Wang, Hai-Bo
Liu, Xiang-Ping
Zhou, Fang
Xiang, Jin-Yu
Yao, Ru-Yong
Niu, Hai-Tao
CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis
title CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis
title_full CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis
title_fullStr CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis
title_full_unstemmed CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis
title_short CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis
title_sort crm1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920404/
https://www.ncbi.nlm.nih.gov/pubmed/29725458
http://dx.doi.org/10.3892/ol.2018.8316
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