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Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability

Background: Children with autism spectrum disorder (ASD) require neurological evaluation to detect sensory-motor impairment. This will improve understanding of brain function in children with ASD, in terms of minor neurological dysfunctions (MNDs). Methods: We compared 32 ASD children without intell...

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Autores principales: Tripi, Gabriele, Roux, Sylvie, Carotenuto, Marco, Bonnet-Brilhault, Frédérique, Roccella, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920453/
https://www.ncbi.nlm.nih.gov/pubmed/29649181
http://dx.doi.org/10.3390/jcm7040079
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author Tripi, Gabriele
Roux, Sylvie
Carotenuto, Marco
Bonnet-Brilhault, Frédérique
Roccella, Michele
author_facet Tripi, Gabriele
Roux, Sylvie
Carotenuto, Marco
Bonnet-Brilhault, Frédérique
Roccella, Michele
author_sort Tripi, Gabriele
collection PubMed
description Background: Children with autism spectrum disorder (ASD) require neurological evaluation to detect sensory-motor impairment. This will improve understanding of brain function in children with ASD, in terms of minor neurological dysfunctions (MNDs). Methods: We compared 32 ASD children without intellectual disability (IQ ≥ 70) with 32 healthy controls. A standardized and age-specific neurological examination according to Touwen was used to detect the presence of MNDs. Particular attention was paid to severity and type of MNDs. Results: Children with ASD had significantly higher rates of MNDs compared to controls (96.9% versus 15.6%): 81.3% had simple MNDs (p < 0.0001) and 15.6% had complex MNDs (p = 0.053). The prevalence of MNDs in the ASD group was significantly higher (p < 0.0001) than controls. With respect to specific types of MNDs, children with ASD showed a wide range of fine manipulative disability, sensory deficits and choreiform dyskinesia. We also found an excess of associated movements and anomalies in coordination and balance. Conclusions: Results replicate previous findings which found delays in sensory-motor behavior in ASD pointing towards a role for prenatal, natal and neonatal risk factors in the neurodevelopmental theory of autism.
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spelling pubmed-59204532018-04-30 Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability Tripi, Gabriele Roux, Sylvie Carotenuto, Marco Bonnet-Brilhault, Frédérique Roccella, Michele J Clin Med Article Background: Children with autism spectrum disorder (ASD) require neurological evaluation to detect sensory-motor impairment. This will improve understanding of brain function in children with ASD, in terms of minor neurological dysfunctions (MNDs). Methods: We compared 32 ASD children without intellectual disability (IQ ≥ 70) with 32 healthy controls. A standardized and age-specific neurological examination according to Touwen was used to detect the presence of MNDs. Particular attention was paid to severity and type of MNDs. Results: Children with ASD had significantly higher rates of MNDs compared to controls (96.9% versus 15.6%): 81.3% had simple MNDs (p < 0.0001) and 15.6% had complex MNDs (p = 0.053). The prevalence of MNDs in the ASD group was significantly higher (p < 0.0001) than controls. With respect to specific types of MNDs, children with ASD showed a wide range of fine manipulative disability, sensory deficits and choreiform dyskinesia. We also found an excess of associated movements and anomalies in coordination and balance. Conclusions: Results replicate previous findings which found delays in sensory-motor behavior in ASD pointing towards a role for prenatal, natal and neonatal risk factors in the neurodevelopmental theory of autism. MDPI 2018-04-12 /pmc/articles/PMC5920453/ /pubmed/29649181 http://dx.doi.org/10.3390/jcm7040079 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tripi, Gabriele
Roux, Sylvie
Carotenuto, Marco
Bonnet-Brilhault, Frédérique
Roccella, Michele
Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability
title Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability
title_full Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability
title_fullStr Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability
title_full_unstemmed Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability
title_short Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability
title_sort minor neurological dysfunctions (mnds) in autistic children without intellectual disability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920453/
https://www.ncbi.nlm.nih.gov/pubmed/29649181
http://dx.doi.org/10.3390/jcm7040079
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