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Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability
Background: Children with autism spectrum disorder (ASD) require neurological evaluation to detect sensory-motor impairment. This will improve understanding of brain function in children with ASD, in terms of minor neurological dysfunctions (MNDs). Methods: We compared 32 ASD children without intell...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920453/ https://www.ncbi.nlm.nih.gov/pubmed/29649181 http://dx.doi.org/10.3390/jcm7040079 |
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author | Tripi, Gabriele Roux, Sylvie Carotenuto, Marco Bonnet-Brilhault, Frédérique Roccella, Michele |
author_facet | Tripi, Gabriele Roux, Sylvie Carotenuto, Marco Bonnet-Brilhault, Frédérique Roccella, Michele |
author_sort | Tripi, Gabriele |
collection | PubMed |
description | Background: Children with autism spectrum disorder (ASD) require neurological evaluation to detect sensory-motor impairment. This will improve understanding of brain function in children with ASD, in terms of minor neurological dysfunctions (MNDs). Methods: We compared 32 ASD children without intellectual disability (IQ ≥ 70) with 32 healthy controls. A standardized and age-specific neurological examination according to Touwen was used to detect the presence of MNDs. Particular attention was paid to severity and type of MNDs. Results: Children with ASD had significantly higher rates of MNDs compared to controls (96.9% versus 15.6%): 81.3% had simple MNDs (p < 0.0001) and 15.6% had complex MNDs (p = 0.053). The prevalence of MNDs in the ASD group was significantly higher (p < 0.0001) than controls. With respect to specific types of MNDs, children with ASD showed a wide range of fine manipulative disability, sensory deficits and choreiform dyskinesia. We also found an excess of associated movements and anomalies in coordination and balance. Conclusions: Results replicate previous findings which found delays in sensory-motor behavior in ASD pointing towards a role for prenatal, natal and neonatal risk factors in the neurodevelopmental theory of autism. |
format | Online Article Text |
id | pubmed-5920453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59204532018-04-30 Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability Tripi, Gabriele Roux, Sylvie Carotenuto, Marco Bonnet-Brilhault, Frédérique Roccella, Michele J Clin Med Article Background: Children with autism spectrum disorder (ASD) require neurological evaluation to detect sensory-motor impairment. This will improve understanding of brain function in children with ASD, in terms of minor neurological dysfunctions (MNDs). Methods: We compared 32 ASD children without intellectual disability (IQ ≥ 70) with 32 healthy controls. A standardized and age-specific neurological examination according to Touwen was used to detect the presence of MNDs. Particular attention was paid to severity and type of MNDs. Results: Children with ASD had significantly higher rates of MNDs compared to controls (96.9% versus 15.6%): 81.3% had simple MNDs (p < 0.0001) and 15.6% had complex MNDs (p = 0.053). The prevalence of MNDs in the ASD group was significantly higher (p < 0.0001) than controls. With respect to specific types of MNDs, children with ASD showed a wide range of fine manipulative disability, sensory deficits and choreiform dyskinesia. We also found an excess of associated movements and anomalies in coordination and balance. Conclusions: Results replicate previous findings which found delays in sensory-motor behavior in ASD pointing towards a role for prenatal, natal and neonatal risk factors in the neurodevelopmental theory of autism. MDPI 2018-04-12 /pmc/articles/PMC5920453/ /pubmed/29649181 http://dx.doi.org/10.3390/jcm7040079 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tripi, Gabriele Roux, Sylvie Carotenuto, Marco Bonnet-Brilhault, Frédérique Roccella, Michele Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability |
title | Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability |
title_full | Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability |
title_fullStr | Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability |
title_full_unstemmed | Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability |
title_short | Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability |
title_sort | minor neurological dysfunctions (mnds) in autistic children without intellectual disability |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920453/ https://www.ncbi.nlm.nih.gov/pubmed/29649181 http://dx.doi.org/10.3390/jcm7040079 |
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