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Characterization of a Novel Human Tumor Necrosis Factor‐α Mutant with Increased Cytotoxic Activity

Various novel recombinant human tumor necrosis factor‐α (TNF) mutants were prepared using protein engineering techniques, and their cytotoxic activity was compared with that of the intact form of TNF (intact TNF). Mutant 471 (a TNF mutant molecule with the deletion of 7 amino acids at the amino‐term...

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Detalles Bibliográficos
Autores principales:	Masegi, Tsukio, Kato, Arata, Kitai, Kazuo, Fukuoka, Masami, Ogawa, Hiroko, Ichikawa, Yataro, Nakamura, Satoshi, Watanabe, Naoki, Niitsu, Yoshiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1995
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920582/ https://www.ncbi.nlm.nih.gov/pubmed/7737913 http://dx.doi.org/10.1111/j.1349-7006.1995.tb02990.x

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