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Microsatellite Instability and Other Molecular Abnormalities in Human Prostate Cancer

Microsatellites are highly polymorphic, short‐tandem repeat sequences dispersed throughout the genome. Instability of these repeat sequences at multiple genetic loci may result from mismatch repair errors, and occurs in hereditary nonpolyposis colorectal carcinoma and certain sporadic cancers. To ex...

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Autores principales: Suzuki, Hiroyoshi, Komiya, Akira, Aida, Sara, Akimoto, Susumu, Shiraishi, Taizo, Yatani, Ryuichi, Igarashi, Tatsuo, Shimazaki, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1995
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920592/
https://www.ncbi.nlm.nih.gov/pubmed/7493915
http://dx.doi.org/10.1111/j.1349-7006.1995.tb03007.x
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author Suzuki, Hiroyoshi
Komiya, Akira
Aida, Sara
Akimoto, Susumu
Shiraishi, Taizo
Yatani, Ryuichi
Igarashi, Tatsuo
Shimazaki, Jun
author_facet Suzuki, Hiroyoshi
Komiya, Akira
Aida, Sara
Akimoto, Susumu
Shiraishi, Taizo
Yatani, Ryuichi
Igarashi, Tatsuo
Shimazaki, Jun
author_sort Suzuki, Hiroyoshi
collection PubMed
description Microsatellites are highly polymorphic, short‐tandem repeat sequences dispersed throughout the genome. Instability of these repeat sequences at multiple genetic loci may result from mismatch repair errors, and occurs in hereditary nonpolyposis colorectal carcinoma and certain sporadic cancers. To examine microsatellite instability during the pathogenesis of human prostate cancer, we screened 48 prostate cancer cases (20 stage B, 10 stage C and 18 endocrine therapy‐resistant cancer‐death cases) for replication error at 17 microsatellite marker loci on 9 chromosomes. Microsatellite instabilities were found in 7 of 48 cases (14.6%), and all 7 cases showing the instability were poorly differentiated adenocarcinomas. Moreover, microsatellite instabilities were more frequently observed in cancer‐death cases (6/18, 33%) than in stage B+C cases (1/30, 3.3%). These data suggest that micro‐satellite instability is an important genetic change related to the progression of a subset of human prostate cancer cases. It is suggested to be associated with extensive, concurrent molecular changes including androgen receptor gene mutations, as well as frequent loss of heterozygosity at chromosomal regions 8p, 10q, and 16q.
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spelling pubmed-59205922018-05-11 Microsatellite Instability and Other Molecular Abnormalities in Human Prostate Cancer Suzuki, Hiroyoshi Komiya, Akira Aida, Sara Akimoto, Susumu Shiraishi, Taizo Yatani, Ryuichi Igarashi, Tatsuo Shimazaki, Jun Jpn J Cancer Res Article Microsatellites are highly polymorphic, short‐tandem repeat sequences dispersed throughout the genome. Instability of these repeat sequences at multiple genetic loci may result from mismatch repair errors, and occurs in hereditary nonpolyposis colorectal carcinoma and certain sporadic cancers. To examine microsatellite instability during the pathogenesis of human prostate cancer, we screened 48 prostate cancer cases (20 stage B, 10 stage C and 18 endocrine therapy‐resistant cancer‐death cases) for replication error at 17 microsatellite marker loci on 9 chromosomes. Microsatellite instabilities were found in 7 of 48 cases (14.6%), and all 7 cases showing the instability were poorly differentiated adenocarcinomas. Moreover, microsatellite instabilities were more frequently observed in cancer‐death cases (6/18, 33%) than in stage B+C cases (1/30, 3.3%). These data suggest that micro‐satellite instability is an important genetic change related to the progression of a subset of human prostate cancer cases. It is suggested to be associated with extensive, concurrent molecular changes including androgen receptor gene mutations, as well as frequent loss of heterozygosity at chromosomal regions 8p, 10q, and 16q. Blackwell Publishing Ltd 1995-10 /pmc/articles/PMC5920592/ /pubmed/7493915 http://dx.doi.org/10.1111/j.1349-7006.1995.tb03007.x Text en
spellingShingle Article
Suzuki, Hiroyoshi
Komiya, Akira
Aida, Sara
Akimoto, Susumu
Shiraishi, Taizo
Yatani, Ryuichi
Igarashi, Tatsuo
Shimazaki, Jun
Microsatellite Instability and Other Molecular Abnormalities in Human Prostate Cancer
title Microsatellite Instability and Other Molecular Abnormalities in Human Prostate Cancer
title_full Microsatellite Instability and Other Molecular Abnormalities in Human Prostate Cancer
title_fullStr Microsatellite Instability and Other Molecular Abnormalities in Human Prostate Cancer
title_full_unstemmed Microsatellite Instability and Other Molecular Abnormalities in Human Prostate Cancer
title_short Microsatellite Instability and Other Molecular Abnormalities in Human Prostate Cancer
title_sort microsatellite instability and other molecular abnormalities in human prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920592/
https://www.ncbi.nlm.nih.gov/pubmed/7493915
http://dx.doi.org/10.1111/j.1349-7006.1995.tb03007.x
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