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Protective Effects of Kampo Medicines and Baicalin against Intestinal Toxicity of a New Anticancer Camptothecin Derivative, Irinotecan Hydrochloride (CPT‐11), in Rats

In clinical use, irinotecan hydrochloride (CPT‐11; 7‐ethyl‐10‐[4‐(piperidmo)‐l‐piperidino]carbonyl‐oxycamptothecin), a novel antitumor agent, causes a relatively high incidence of severe forms of diarrhea. We investigated whether baicalin, an inhibitor of β‐glucuronidase, which deconjugates the gluc...

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Detalles Bibliográficos
Autores principales:	Takasuna, Kiyoshi, Kasai, Yoshio, Kitano, Yutaka, Mori, Kazuhiko, Kobayashi, Reiko, Hagiwara, Takehiro, Kakihata, Kohji, Hirohashi, Masaaki, Nomura, Mamoru, Nagai, Eiichi, Kamataki, Tetsuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1995
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920598/ https://www.ncbi.nlm.nih.gov/pubmed/7493918 http://dx.doi.org/10.1111/j.1349-7006.1995.tb03010.x

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