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Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3

Telomeres, at the end of chromosomes, shorten with each cell division, resulting in cellular senescence. Tumor cells, unlike normal somatic cells, express a telomerase that maintains the telomere length. Deletion of a gene(s) on chromosome 3 is common in human renal cell carcinoma (RCC) and reintrod...

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Autores principales: Ohmura, Hiroshi, Tahara, Hidetoshi, Suzuki, Mikio, Ide, Toshinori, Shimizu, Motoyuki, Yoshida, Mitsuaki A., Tahara, Eiichi, Shay, Jerry W., Barrett, J. Carl, Oshimura, Mitsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1995
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920601/
https://www.ncbi.nlm.nih.gov/pubmed/7493906
http://dx.doi.org/10.1111/j.1349-7006.1995.tb02998.x
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author Ohmura, Hiroshi
Tahara, Hidetoshi
Suzuki, Mikio
Ide, Toshinori
Shimizu, Motoyuki
Yoshida, Mitsuaki A.
Tahara, Eiichi
Shay, Jerry W.
Barrett, J. Carl
Oshimura, Mitsuo
author_facet Ohmura, Hiroshi
Tahara, Hidetoshi
Suzuki, Mikio
Ide, Toshinori
Shimizu, Motoyuki
Yoshida, Mitsuaki A.
Tahara, Eiichi
Shay, Jerry W.
Barrett, J. Carl
Oshimura, Mitsuo
author_sort Ohmura, Hiroshi
collection PubMed
description Telomeres, at the end of chromosomes, shorten with each cell division, resulting in cellular senescence. Tumor cells, unlike normal somatic cells, express a telomerase that maintains the telomere length. Deletion of a gene(s) on chromosome 3 is common in human renal cell carcinoma (RCC) and reintroduction of a normal chromosome 3 into an RCC immortal cell line restored the program of cellular senescence. The loss of indefinite growth potential was associated with the loss of telomerase activity and shortening of telomeres in the RCC cells with a normal chromosome 3. However, microcell hybrids that escaped from senescence and microcell hybrids with an introduced chromosome 7 or 11 maintained telomere lengths and telomerase activity similar to those of the parental RCC23. Thus, restoration of the cellular senescence program by chromosome 3 is associated with repression of telomerase function in RCC cells.
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spelling pubmed-59206012018-05-11 Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3 Ohmura, Hiroshi Tahara, Hidetoshi Suzuki, Mikio Ide, Toshinori Shimizu, Motoyuki Yoshida, Mitsuaki A. Tahara, Eiichi Shay, Jerry W. Barrett, J. Carl Oshimura, Mitsuo Jpn J Cancer Res Rapid Communication Telomeres, at the end of chromosomes, shorten with each cell division, resulting in cellular senescence. Tumor cells, unlike normal somatic cells, express a telomerase that maintains the telomere length. Deletion of a gene(s) on chromosome 3 is common in human renal cell carcinoma (RCC) and reintroduction of a normal chromosome 3 into an RCC immortal cell line restored the program of cellular senescence. The loss of indefinite growth potential was associated with the loss of telomerase activity and shortening of telomeres in the RCC cells with a normal chromosome 3. However, microcell hybrids that escaped from senescence and microcell hybrids with an introduced chromosome 7 or 11 maintained telomere lengths and telomerase activity similar to those of the parental RCC23. Thus, restoration of the cellular senescence program by chromosome 3 is associated with repression of telomerase function in RCC cells. Blackwell Publishing Ltd 1995-10 /pmc/articles/PMC5920601/ /pubmed/7493906 http://dx.doi.org/10.1111/j.1349-7006.1995.tb02998.x Text en
spellingShingle Rapid Communication
Ohmura, Hiroshi
Tahara, Hidetoshi
Suzuki, Mikio
Ide, Toshinori
Shimizu, Motoyuki
Yoshida, Mitsuaki A.
Tahara, Eiichi
Shay, Jerry W.
Barrett, J. Carl
Oshimura, Mitsuo
Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3
title Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3
title_full Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3
title_fullStr Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3
title_full_unstemmed Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3
title_short Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3
title_sort restoration of the cellular senescence program and repression of telomerase by human chromosome 3
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920601/
https://www.ncbi.nlm.nih.gov/pubmed/7493906
http://dx.doi.org/10.1111/j.1349-7006.1995.tb02998.x
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