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Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3
Telomeres, at the end of chromosomes, shorten with each cell division, resulting in cellular senescence. Tumor cells, unlike normal somatic cells, express a telomerase that maintains the telomere length. Deletion of a gene(s) on chromosome 3 is common in human renal cell carcinoma (RCC) and reintrod...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1995
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920601/ https://www.ncbi.nlm.nih.gov/pubmed/7493906 http://dx.doi.org/10.1111/j.1349-7006.1995.tb02998.x |
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author | Ohmura, Hiroshi Tahara, Hidetoshi Suzuki, Mikio Ide, Toshinori Shimizu, Motoyuki Yoshida, Mitsuaki A. Tahara, Eiichi Shay, Jerry W. Barrett, J. Carl Oshimura, Mitsuo |
author_facet | Ohmura, Hiroshi Tahara, Hidetoshi Suzuki, Mikio Ide, Toshinori Shimizu, Motoyuki Yoshida, Mitsuaki A. Tahara, Eiichi Shay, Jerry W. Barrett, J. Carl Oshimura, Mitsuo |
author_sort | Ohmura, Hiroshi |
collection | PubMed |
description | Telomeres, at the end of chromosomes, shorten with each cell division, resulting in cellular senescence. Tumor cells, unlike normal somatic cells, express a telomerase that maintains the telomere length. Deletion of a gene(s) on chromosome 3 is common in human renal cell carcinoma (RCC) and reintroduction of a normal chromosome 3 into an RCC immortal cell line restored the program of cellular senescence. The loss of indefinite growth potential was associated with the loss of telomerase activity and shortening of telomeres in the RCC cells with a normal chromosome 3. However, microcell hybrids that escaped from senescence and microcell hybrids with an introduced chromosome 7 or 11 maintained telomere lengths and telomerase activity similar to those of the parental RCC23. Thus, restoration of the cellular senescence program by chromosome 3 is associated with repression of telomerase function in RCC cells. |
format | Online Article Text |
id | pubmed-5920601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1995 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59206012018-05-11 Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3 Ohmura, Hiroshi Tahara, Hidetoshi Suzuki, Mikio Ide, Toshinori Shimizu, Motoyuki Yoshida, Mitsuaki A. Tahara, Eiichi Shay, Jerry W. Barrett, J. Carl Oshimura, Mitsuo Jpn J Cancer Res Rapid Communication Telomeres, at the end of chromosomes, shorten with each cell division, resulting in cellular senescence. Tumor cells, unlike normal somatic cells, express a telomerase that maintains the telomere length. Deletion of a gene(s) on chromosome 3 is common in human renal cell carcinoma (RCC) and reintroduction of a normal chromosome 3 into an RCC immortal cell line restored the program of cellular senescence. The loss of indefinite growth potential was associated with the loss of telomerase activity and shortening of telomeres in the RCC cells with a normal chromosome 3. However, microcell hybrids that escaped from senescence and microcell hybrids with an introduced chromosome 7 or 11 maintained telomere lengths and telomerase activity similar to those of the parental RCC23. Thus, restoration of the cellular senescence program by chromosome 3 is associated with repression of telomerase function in RCC cells. Blackwell Publishing Ltd 1995-10 /pmc/articles/PMC5920601/ /pubmed/7493906 http://dx.doi.org/10.1111/j.1349-7006.1995.tb02998.x Text en |
spellingShingle | Rapid Communication Ohmura, Hiroshi Tahara, Hidetoshi Suzuki, Mikio Ide, Toshinori Shimizu, Motoyuki Yoshida, Mitsuaki A. Tahara, Eiichi Shay, Jerry W. Barrett, J. Carl Oshimura, Mitsuo Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3 |
title | Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3 |
title_full | Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3 |
title_fullStr | Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3 |
title_full_unstemmed | Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3 |
title_short | Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3 |
title_sort | restoration of the cellular senescence program and repression of telomerase by human chromosome 3 |
topic | Rapid Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920601/ https://www.ncbi.nlm.nih.gov/pubmed/7493906 http://dx.doi.org/10.1111/j.1349-7006.1995.tb02998.x |
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