Cargando…

Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery

[Image: see text] Cell-penetrating peptides (CPPs) can facilitate the intracellular delivery of large therapeutically relevant molecules, including proteins and oligonucleotides. Although hundreds of CPP sequences are described in the literature, predicting efficacious sequences remains difficult. H...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wolfe, Justin M., Fadzen, Colin M., Choo, Zi-Ning, Holden, Rebecca L., Yao, Monica, Hanson, Gunnar J., Pentelute, Bradley L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920612/ https://www.ncbi.nlm.nih.gov/pubmed/29721534 http://dx.doi.org/10.1021/acscentsci.8b00098

Ejemplares similares

Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity
por: Schissel, Carly K., et al.
Publicado: (2022)

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
por: Cho, Choi-Fong, et al.
Publicado: (2017)

Deep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers
por: López-Vidal, Eva M., et al.
Publicado: (2021)

Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity
por: Backlund, Coralie M., et al.
Publicado: (2022)

Delivery of antisense oligonucleotide using polyethylenimine-based lipid nanoparticle modified with cell penetrating peptide
por: Yang, Shuang, et al.
Publicado: (2019)

A Tumor-Homing Peptide Platform Enhances Drug Solubility, Improves Blood–Brain Barrier Permeability and Targets Glioblastoma
por: Cho, Choi-Fong, et al.
Publicado: (2022)

A cell-penetrating peptide enhances delivery and efficacy of phosphorodiamidate morpholino oligomers in mdx mice
por: Gan, Li, et al.
Publicado: (2022)

Enhancing Antisense Oligonucleotide-Based Therapeutic Delivery with DG9, a Versatile Cell-Penetrating Peptide
por: Haque, Umme Sabrina, et al.
Publicado: (2023)

Delivery of Antisense Peptide Nucleic Acids to Cells by Conjugation with Small Arginine-Rich Cell-Penetrating Peptide (R/W)9
por: Cordier, Céline, et al.
Publicado: (2014)

Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers
por: Li, Chengxi, et al.
Publicado: (2021)

Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo
por: Bazaz, Safa, et al.
Publicado: (2021)

Impact of different cell penetrating peptides on the efficacy of antisense therapeutics for targeting intracellular pathogens
por: Abushahba, Mostafa F. N., et al.
Publicado: (2016)

Palladium–peptide oxidative addition complexes for bioconjugation
por: Rojas, Anthony J., et al.
Publicado: (2022)

Intracellular oligonucleotide delivery using the cell penetrating peptide Xentry
por: Coutinho, Frazer P., et al.
Publicado: (2018)

Cell Penetrating Peptides in the Delivery of Biopharmaceuticals
por: Munyendo, Were LL, et al.
Publicado: (2012)

Machine Learning Guides Peptide Nucleic Acid Flow Synthesis and Sequence Design
por: Li, Chengxi, et al.
Publicado: (2022)

Delivery of mirror image polypeptides into cells
por: Rabideau, Amy E., et al.
Publicado: (2015)

Enzyme-Catalyzed Macrocyclization of Long Unprotected Peptides
por: Zhang, Chi, et al.
Publicado: (2014)

Delivery of therapeutic oligonucleotides with cell penetrating peptides()
por: Boisguérin, Prisca, et al.
Publicado: (2015)

Prediction of Cell Penetrating Peptides by Support Vector Machines
por: Sanders, William S., et al.
Publicado: (2011)

Delivery of antisense oligonucleotides for splice‐correction of androgen receptor pre‐mRNA in castration‐resistant prostate cancer models using cell‐penetrating peptides
por: Luna Velez, Maria V., et al.
Publicado: (2022)

Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA
por: Järver, Peter, et al.
Publicado: (2012)

Unravelling cytosolic delivery of cell penetrating peptides with a quantitative endosomal escape assay
por: Teo, Serena L. Y., et al.
Publicado: (2021)

An Umpolung Approach for the Chemoselective Arylation of Selenocysteine in Unprotected Peptides
por: Cohen, Daniel T., et al.
Publicado: (2015)

Delivery of Antibody Mimics into Mammalian Cells via Anthrax Toxin Protective Antigen
por: Liao, Xiaoli, et al.
Publicado: (2014)

Cell-Penetrating Peptides: Efficient Vectors for Vaccine Delivery
por: Yang, Jieru, et al.
Publicado: (2019)

Ocular Delivery of Therapeutic Agents by Cell-Penetrating Peptides
por: Nhàn, Nguyễn Thị Thanh, et al.
Publicado: (2023)

DIPG-41. EXPLORING BRAIN PENETRANT PEPTIDE-DRUG CONJUGATES IN DIFFUSE INTRINSIC PONTINE GLIOMA MODELS
por: Clark, Jasmine, et al.
Publicado: (2023)

Delivery of Nucleic Acids and Nanomaterials by Cell-Penetrating Peptides: Opportunities and Challenges
por: Huang, Yue-Wern, et al.
Publicado: (2015)

Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis
por: Alam, Md Rowshon, et al.
Publicado: (2008)

Cell-penetrating peptides and their analogues as novel nanocarriers for drug delivery
por: Jafari, Samira, et al.
Publicado: (2015)

Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides
por: Lin, Tingting, et al.
Publicado: (2016)

Cell-Penetrating Peptides to Enhance Delivery of Oligonucleotide-Based Therapeutics
por: McClorey, Graham, et al.
Publicado: (2018)

Versatility of cell-penetrating peptides for intracellular delivery of siRNA
por: Singh, Tejinder, et al.
Publicado: (2018)

The Utilization of Cell-Penetrating Peptides in the Intracellular Delivery of Viral Nanoparticles
por: Váňová, Jana, et al.
Publicado: (2019)

Cell-Penetrating Peptides: Emerging Tools for mRNA Delivery
por: Yokoo, Hidetomo, et al.
Publicado: (2021)

Automated affinity selection for rapid discovery of peptide binders
por: Zhang, Genwei, et al.
Publicado: (2021)

Novel Lung Targeting Cell Penetrating Peptides as Vectors for Delivery of Therapeutics
por: McCandless, Kayla, et al.
Publicado: (2021)

Cyclic Peptides to Improve Delivery and Exon Skipping of Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy
por: Jirka, Silvana M.G., et al.
Publicado: (2018)

Delivery of cell-penetrating peptide-peptide nucleic acid conjugates by assembly on an oligonucleotide scaffold
por: Zhao, Xing-Liang, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_5nns0hcd6fkq6cibcjlrda112j