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Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors

One of the resistance mechanisms to folate‐based thymidylate synthase (TS) inhibitors is the increase in TS activity in tumor cells. Human B lymphoblastoid cell line (W1L2) was made resistant to a lipophilic non‐polyglutamatable TS inhibitor (ZM249148), and the subline (W1L2:R179) showed a 20‐fold i...

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Detalles Bibliográficos
Autores principales:	Kobayashi, Hiroyuki, Takemura, Yuzuru, Miyachi, Hayato, Skelton, Lorraine, Jackman, Ann L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1995
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920622/ https://www.ncbi.nlm.nih.gov/pubmed/8567390 http://dx.doi.org/10.1111/j.1349-7006.1995.tb03014.x

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