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Effects of Nine Active Ingredients in Chinese Herbal Medicine Sho‐saiko‐to on 2‐(2‐Furyl)‐3‐(5‐nitro‐2‐furyl)acryIamide Mutagenicity
The antimutagenic effects of nine active compounds in the Chinese herbal medicine “sho‐saiko‐to” on mutagenesis induced by a direct‐acting mutagen, 2‐(2‐furyI)‐3‐(5‐nitro‐2‐furyl)acrylamide (AF‐2) were investigated in Salmonella typhimurium, strain TA100. The active compounds examined were classifie...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1995
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920669/ https://www.ncbi.nlm.nih.gov/pubmed/8636000 http://dx.doi.org/10.1111/j.1349-7006.1995.tb03305.x |
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author | Ohtsuka, Masanori Fukuda, Kazunori Yano, Hirohisa Kojiro, Masamichi |
author_facet | Ohtsuka, Masanori Fukuda, Kazunori Yano, Hirohisa Kojiro, Masamichi |
author_sort | Ohtsuka, Masanori |
collection | PubMed |
description | The antimutagenic effects of nine active compounds in the Chinese herbal medicine “sho‐saiko‐to” on mutagenesis induced by a direct‐acting mutagen, 2‐(2‐furyI)‐3‐(5‐nitro‐2‐furyl)acrylamide (AF‐2) were investigated in Salmonella typhimurium, strain TA100. The active compounds examined were classified into two major groups, saponins and flavonoids, the former comprising glycyrrhizin, saikosaponins a, c and d, and ginsenosides Rbl and Rgl, and the latter, baicalin, baicalein and wogonin. Saikosaponin a and ginsenoside Rbl were found to reduce the mutagenicity of AF‐2 significantly when applied post‐AF‐2‐treatment in the Salmonella mutagenicity assay. Ginsenoside Rbl also decreased the mutagenic activity of AF‐2 in a simultaneous treatment protocol. The results indicate that saikosaponin a and ginsenoside Rbl may enhance DNA repair, and ginsenoside Rbl may also have the ability to inactivate the mutagenic activity of AF‐2 directly. On the other hand, saikosaponin d and baicalin showed a slight enhancing effect. None of the compounds, except baicalein, showed any toxic effect on the test strain. These findings may be useful for the development of chemopreventive agents. |
format | Online Article Text |
id | pubmed-5920669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1995 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59206692018-05-11 Effects of Nine Active Ingredients in Chinese Herbal Medicine Sho‐saiko‐to on 2‐(2‐Furyl)‐3‐(5‐nitro‐2‐furyl)acryIamide Mutagenicity Ohtsuka, Masanori Fukuda, Kazunori Yano, Hirohisa Kojiro, Masamichi Jpn J Cancer Res Article The antimutagenic effects of nine active compounds in the Chinese herbal medicine “sho‐saiko‐to” on mutagenesis induced by a direct‐acting mutagen, 2‐(2‐furyI)‐3‐(5‐nitro‐2‐furyl)acrylamide (AF‐2) were investigated in Salmonella typhimurium, strain TA100. The active compounds examined were classified into two major groups, saponins and flavonoids, the former comprising glycyrrhizin, saikosaponins a, c and d, and ginsenosides Rbl and Rgl, and the latter, baicalin, baicalein and wogonin. Saikosaponin a and ginsenoside Rbl were found to reduce the mutagenicity of AF‐2 significantly when applied post‐AF‐2‐treatment in the Salmonella mutagenicity assay. Ginsenoside Rbl also decreased the mutagenic activity of AF‐2 in a simultaneous treatment protocol. The results indicate that saikosaponin a and ginsenoside Rbl may enhance DNA repair, and ginsenoside Rbl may also have the ability to inactivate the mutagenic activity of AF‐2 directly. On the other hand, saikosaponin d and baicalin showed a slight enhancing effect. None of the compounds, except baicalein, showed any toxic effect on the test strain. These findings may be useful for the development of chemopreventive agents. Blackwell Publishing Ltd 1995-12 /pmc/articles/PMC5920669/ /pubmed/8636000 http://dx.doi.org/10.1111/j.1349-7006.1995.tb03305.x Text en |
spellingShingle | Article Ohtsuka, Masanori Fukuda, Kazunori Yano, Hirohisa Kojiro, Masamichi Effects of Nine Active Ingredients in Chinese Herbal Medicine Sho‐saiko‐to on 2‐(2‐Furyl)‐3‐(5‐nitro‐2‐furyl)acryIamide Mutagenicity |
title | Effects of Nine Active Ingredients in Chinese Herbal Medicine Sho‐saiko‐to on 2‐(2‐Furyl)‐3‐(5‐nitro‐2‐furyl)acryIamide Mutagenicity |
title_full | Effects of Nine Active Ingredients in Chinese Herbal Medicine Sho‐saiko‐to on 2‐(2‐Furyl)‐3‐(5‐nitro‐2‐furyl)acryIamide Mutagenicity |
title_fullStr | Effects of Nine Active Ingredients in Chinese Herbal Medicine Sho‐saiko‐to on 2‐(2‐Furyl)‐3‐(5‐nitro‐2‐furyl)acryIamide Mutagenicity |
title_full_unstemmed | Effects of Nine Active Ingredients in Chinese Herbal Medicine Sho‐saiko‐to on 2‐(2‐Furyl)‐3‐(5‐nitro‐2‐furyl)acryIamide Mutagenicity |
title_short | Effects of Nine Active Ingredients in Chinese Herbal Medicine Sho‐saiko‐to on 2‐(2‐Furyl)‐3‐(5‐nitro‐2‐furyl)acryIamide Mutagenicity |
title_sort | effects of nine active ingredients in chinese herbal medicine sho‐saiko‐to on 2‐(2‐furyl)‐3‐(5‐nitro‐2‐furyl)acryiamide mutagenicity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920669/ https://www.ncbi.nlm.nih.gov/pubmed/8636000 http://dx.doi.org/10.1111/j.1349-7006.1995.tb03305.x |
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