Cargando…

EPEC NleH1 is significantly more effective in reversing colitis and reducing mortality than NleH2 via differential effects on host signaling pathways

Enteropathogenic Escherichia coli (EPEC) is a foodborne pathogen that uses a type III secretion system to translocate effector molecules into host intestinal epithelial cells (IEC) subverting several host cell processes and signaling cascades. Interestingly, EPEC infection induces only modest intest...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kralicek, Sarah E., Nguyen, Mai, Rhee, Ki-Jong, Tapia, Rocio, Hecht, Gail
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920738/ https://www.ncbi.nlm.nih.gov/pubmed/29396422 http://dx.doi.org/10.1038/s41374-017-0016-1

Ejemplares similares

Expression and Regulation of the Escherichia coli O157:H7 Effector Proteins NleH1 and NleH2
por: Holmes, Ashleigh, et al.
Publicado: (2012)

Hsp90 Interacts with the Bacterial Effector NleH1
por: Wu, Miaomiao, et al.
Publicado: (2018)

Influence of Intestinal Microbiota Transplantation and NleH Expression on Citrobacter rodentium Colonization of Mice
por: Wang, Gaochan, et al.
Publicado: (2018)

The enteropathogenic Escherichia coli effector NleH inhibits apoptosis induced by Clostridium difficile toxin B
por: Robinson, Keith S., et al.
Publicado: (2010)

Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli
por: Pollock, Georgina L., et al.
Publicado: (2022)

Binding to Na(+)/H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH
por: Martinez, Eric, et al.
Publicado: (2010)

Topological data analysis gives two folding paths in HP35(nle-nle), double mutant of villin headpiece subdomain
por: Ichinomiya, Takashi
Publicado: (2022)

Enteropathogenic Escherichia coli (EPEC) Recruitment of PAR Polarity Protein Atypical PKCζ to Pedestals and Cell–Cell Contacts Precedes Disruption of Tight Junctions in Intestinal Epithelial Cells
por: Tapia, Rocio, et al.
Publicado: (2020)

The E. coli Effector Protein NleF Is a Caspase Inhibitor
por: Blasche, Sonja, et al.
Publicado: (2013)

The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65
por: Newton, Hayley J., et al.
Publicado: (2010)

YM155 Inhibits NleB and SseK Arginine Glycosyltransferase Activity
por: Zhu, Congrui, et al.
Publicado: (2021)

The T3SS Effector Protease NleC Is Active within Citrobacter rodentium
por: Hasan, Md Kamrul, et al.
Publicado: (2021)

The Type III Secretion Effector NleE Inhibits NF-κB Activation
por: Nadler, Chen, et al.
Publicado: (2010)

Enteropathogenic Escherichia coli Uses NleA to Inhibit NLRP3 Inflammasome Activation
por: Yen, Hilo, et al.
Publicado: (2015)

Arg-GlcNAcylation on TRADD by NleB and SseK1 Is Crucial for Bacterial Pathogenesis
por: Xue, Juan, et al.
Publicado: (2020)

Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10
por: Li, Jingxiang, et al.
Publicado: (2021)

The EHEC Type III Effector NleL Is an E3 Ubiquitin Ligase That Modulates Pedestal Formation
por: Piscatelli, Heather, et al.
Publicado: (2011)

Differential expression of the virulence gene nleB among Shiga toxin-producing Escherichia coli strains
por: Cadona, Jimena S., et al.
Publicado: (2020)

NleB2 from enteropathogenic Escherichia coli is a novel arginine-glucose transferase effector
por: Giogha, Cristina, et al.
Publicado: (2021)

Salmonella Phage ST64B Encodes a Member of the SseK/NleB Effector Family
por: Brown, Nat F., et al.
Publicado: (2011)

Quantitative analysis and virulence phenotypes of atypical enteropathogenic Escherichia coli (EPEC) acquired from diarrheal stool samples from a Midwest US hospital
por: Carlino, MJ, et al.
Publicado: (2020)

Proteasome-independent Degradation of Canonical NFκB Complex Components by the NleC Protein of Pathogenic Escherichia coli
por: Mühlen, Sabrina, et al.
Publicado: (2011)

NleG Type 3 Effectors from Enterohaemorrhagic Escherichia coli Are U-Box E3 Ubiquitin Ligases
por: Wu, Bin, et al.
Publicado: (2010)

Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK
por: Sheng, Xiangpeng, et al.
Publicado: (2017)

Identification of NLE1/CDK1 axis as key regulator in the development and progression of non-small cell lung cancer
por: Xu, Pei, et al.
Publicado: (2023)

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation
por: Pearson, Jaclyn S, et al.
Publicado: (2011)

The Structure and Specificity of the Type III Secretion System Effector NleC Suggest a DNA Mimicry Mechanism of Substrate Recognition
por: Turco, Michelle Marian, et al.
Publicado: (2014)

Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway
por: Yao, Qing, et al.
Publicado: (2014)

A Type III Effector NleF from EHEC Inhibits Epithelial Inflammatory Cell Death by Targeting Caspase-4
por: Song, Ting, et al.
Publicado: (2017)

Enterohemorrhagic E. coli effector NleL disrupts host NF-κB signaling by targeting multiple host proteins
por: Sheng, Xiangpeng, et al.
Publicado: (2020)

NleC, a Type III Secretion Protease, Compromises NF-κB Activation by Targeting p65/RelA
por: Yen, Hilo, et al.
Publicado: (2010)

Efficacy of the melanocortin analogue Nle4-D-Phe7-α-melanocyte-stimulating hormone in the treatment of patients with Hailey–Hailey disease
por: Biolcati, G, et al.
Publicado: (2014)

SMAD4 Loss Induces c-MYC–Mediated NLE1 Upregulation to Support Protein Biosynthesis, Colorectal Cancer Growth, and Metastasis
por: Loevenich, Leon P., et al.
Publicado: (2022)

NleB/SseK-catalyzed arginine-glycosylation and enteropathogen virulence are finely tuned by a single variable position contiguous to the catalytic machinery
por: García-García, Ana, et al.
Publicado: (2021)

Metalloprotease NleC Suppresses Host NF-κB/Inflammatory Responses by Cleaving p65 and Interfering with the p65/RPS3 Interaction
por: Hodgson, Andrea, et al.
Publicado: (2015)

Catalytic DxD motif caged in Asx-turn and Met–aromatic interaction attenuates the pathogenic glycosylation of SseK2/NleB2 effectors
por: Koh, Eunhee, et al.
Publicado: (2022)

T3SS-Independent Uptake of the Short-Trip Toxin-Related Recombinant NleC Effector of Enteropathogenic Escherichia coli Leads to NF-κB p65 Cleavage
por: Stolle, Anne-Sophie, et al.
Publicado: (2017)

Author Correction: Catalytic DxD motif caged in Asx-turn and Met–aromatic interaction attenuates the pathogenic glycosylation of SseK2/NleB2 effectors
por: Koh, Eunhee, et al.
Publicado: (2023)

Comparative study of (64)Cu/NOTA-[D-Tyr(6),βAla(11),Thi(13),Nle(14)]BBN(6-14) monomer and dimers for prostate cancer PET imaging
por: Fournier, Patrick, et al.
Publicado: (2012)

[Nle(4), D-Phe(7)]-α-MSH Inhibits Toll-Like Receptor (TLR)2- and TLR4-Induced Microglial Activation and Promotes a M2-Like Phenotype
por: Carniglia, Lila, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_p3tid2vqtqv8oh2nqivrk790qb